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@ARTICLE{Feng:202322,
      author       = {Feng, Lingyan and Lyu, Zhaozi and Offenhäusser, Andreas
                      and Mayer, Dirk},
      title        = {{M}ulti-{L}evel {L}ogic {G}ate {O}peration {B}ased on
                      {A}mplified {A}ptasensor {P}erformance},
      journal      = {Angewandte Chemie / International edition},
      volume       = {54},
      number       = {26},
      issn         = {1433-7851},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2015-04586},
      pages        = {7693 - 7697},
      year         = {2015},
      abstract     = {Conventional electronic circuits can perform multi-level
                      logic operations; however, this capability is rarely
                      realized by biological logic gates. In addition, the
                      question of how to close the gap between biomolecular
                      computation and silicon-based electrical circuitry is still
                      a key issue in the bioelectronics field. Here we explore a
                      novel split aptamer-based multi-level logic gate built from
                      INHIBIT and AND gates that performs a net XOR analysis, with
                      electrochemical signal as output. Based on the
                      aptamer–target interaction and a novel concept of
                      electrochemical rectification, a relayed charge transfer
                      occurs upon target binding between aptamer-linked redox
                      probes and solution-phase probes, which amplifies the sensor
                      signal and facilitates a straightforward and reliable
                      diagnosis. This work reveals a new route for the design of
                      bioelectronic logic circuits that can realize multi-level
                      logic operation, which has the potential to simplify an
                      otherwise complex diagnosis to a “yes” or “no”
                      decision.},
      cin          = {PGI-8 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)PGI-8-20110106 / $I:(DE-82)080009_20140620$},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000356390900045},
      pubmed       = {pmid:25959438},
      doi          = {10.1002/anie.201502315},
      url          = {https://juser.fz-juelich.de/record/202322},
}