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| Hauptseite > Publikationsdatenbank > Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance > print |
| Hauptseite > Publikationsdatenbank > Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance > print |
| 001 | 202322 | ||
| 005 | 20210129220116.0 | ||
| 024 | 7 | _ | |a 10.1002/anie.201502315 |2 doi |
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| 037 | _ | _ | |a FZJ-2015-04586 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Feng, Lingyan |0 P:(DE-Juel1)157885 |b 0 |
| 245 | _ | _ | |a Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance |
| 260 | _ | _ | |a Weinheim |c 2015 |b Wiley-VCH |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1435568568_10716 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision. |
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| 700 | 1 | _ | |a Lyu, Zhaozi |0 P:(DE-Juel1)162320 |b 1 |
| 700 | 1 | _ | |a Offenhäusser, Andreas |0 P:(DE-Juel1)128713 |b 2 |
| 700 | 1 | _ | |a Mayer, Dirk |0 P:(DE-Juel1)128707 |b 3 |e Corresponding Author |
| 773 | _ | _ | |a 10.1002/anie.201502315 |g Vol. 54, no. 26, p. 7693 - 7697 |0 PERI:(DE-600)2011836-3 |n 26 |p 7693 - 7697 |t Angewandte Chemie / International edition |v 54 |y 2015 |x 1433-7851 |
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