TY  - JOUR
AU  - Jakobs, O.
AU  - Langner, R.
AU  - Caspers, S.
AU  - Roski, C.
AU  - Cieslik, E.C.
AU  - Zilles, K.
AU  - Laird, A.R.
AU  - Fox, P. T.
AU  - Eickhoff, S.B.
TI  - Across-study and within-subject functional connectivity of a right-temporo-parietal junction subregion involved in stimulus-context integration
JO  - NeuroImage
VL  - 60
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - PreJuSER-20233
SP  - 2389 - 2398
PY  - 2012
N1  - This work was partly funded by the Human Brain Project (R01-MH074457; A.R.L., S.B.E., P.T.F), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model; K.Z., S.B.E.) and the DFG (IRTG 1328, S.B.E.).
AB  - Bidirectional integration between sensory stimuli and contextual framing is fundamental to action control. Stimuli may entail context-dependent actions, while temporal or spatial characteristics of a stimulus train may establish a contextual framework for upcoming stimuli. Here we aimed at identifying core areas for stimulus-context integration and delineated their functional connectivity (FC) using meta-analytic connectivity modeling (MACM) and analysis of resting-state networks. In a multi-study conjunction, consistently increased activity under higher demands on stimulus-context integration was predominantly found in the right temporo-parietal junction (TPJ), which represented the largest cluster of overlap and was thus used as the seed for the FC analyses. The conjunction between task-dependent (MACM) and task-free (resting state) FC of the right TPJ revealed a shared network comprising bilaterally inferior parietal and frontal cortices, anterior insula, premotor cortex, putamen and cerebellum, i.e., a 'ventral' action/attention network. Stronger task-dependent (vs. task-free) connectivity was observed with the pre-SMA, dorsal premotor cortex, intraparietal sulcus, basal ganglia and primary sensori motor cortex, while stronger resting-state (vs. task-dependent) connectivity was found with the dorsolateral prefrontal and medial parietal cortex. Our data provide strong evidence that the right TPJ may represent a key region for the integration of sensory stimuli and contextual frames in action control. Task-dependent associations with regions related to stimulus processing and motor responses indicate that the right TPJ may integrate 'collaterals' of sensory processing and apply (ensuing) contextual frames, most likely via modulation of preparatory loops. Given the pattern of resting-state connectivity, internal states and goal representations may provide the substrates for the contextual integration within the TPJ in the absence of a specific task.
KW  - Attention: physiology
KW  - Brain: physiology
KW  - Brain Mapping
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Neural Pathways: physiology
KW  - Psychomotor Performance: physiology
KW  - Rest: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22387170
C2  - pmc:PMC3321133
UR  - <Go to ISI:>//WOS:000302926600046
DO  - DOI:10.1016/j.neuroimage.2012.02.037
UR  - https://juser.fz-juelich.de/record/20233
ER  -