%0 Journal Article
%A Caspers, S.
%A Schleicher, A.
%A Bacha-Trams, M.
%A Palomero-Gallagher, N.
%A Amunts, K.
%A Zilles, K.
%T Organization of the Human Inferior Parietal Lobule Based on Receptor Architectonics
%J Cerebral cortex
%V 23
%N 3
%@ 1047-3211
%C Oxford
%I Oxford Univ. Press
%M PreJuSER-20245
%P 615-628
%D 2013
%Z Record converted from VDB: 12.11.2012
%X Human inferior parietal lobule (IPL) plays a key role in various cognitive functions. Its functional diversity, including attention, language, and action processing, is reflected by its structural segregation into 7 cytoarchitectonically distinct areas, each with characteristic connectivity patterns. We hypothesized that commonalities of the cytoarchitectonic, connectional, and functional diversity of the IPL should be reflected by a correlated transmitter receptor-based organization. Since the function of a cortical area requires a well-tuned receptor balance, the densities of 15 different receptors were measured in each IPL area. A hierarchical cluster analysis of the receptor balance revealed a tripartite segregation of the IPL into a rostral, middle, and caudal group. Comparison with other cortical areas showed strong similarities with Broca's region for all 3 groups, with the superior parietal cortex for the middle, and with extrastriate visual areas for the caudal group. Notably, caudal-most area PGp has a receptor fingerprint very similar to that of ventral extrastriate visual cortex. We therefore propose a new organizational model of the human IPL, consisting of 3 clusters, which corresponds to its known cytoarchitectonic, connectional, and functional diversity at the molecular level. This might reflect a general organizational principle of human IPL, beyond specific functional domains.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22375016
%U <Go to ISI:>//WOS:000316275400012
%R 10.1093/cercor/bhs048
%U https://juser.fz-juelich.de/record/20245