TY  - JOUR
AU  - Caspers, S.
AU  - Schleicher, A.
AU  - Bacha-Trams, M.
AU  - Palomero-Gallagher, N.
AU  - Amunts, K.
AU  - Zilles, K.
TI  - Organization of the Human Inferior Parietal Lobule Based on Receptor Architectonics
JO  - Cerebral cortex
VL  - 23
IS  - 3
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-20245
SP  - 615-628
PY  - 2013
N1  - Record converted from VDB: 12.11.2012
AB  - Human inferior parietal lobule (IPL) plays a key role in various cognitive functions. Its functional diversity, including attention, language, and action processing, is reflected by its structural segregation into 7 cytoarchitectonically distinct areas, each with characteristic connectivity patterns. We hypothesized that commonalities of the cytoarchitectonic, connectional, and functional diversity of the IPL should be reflected by a correlated transmitter receptor-based organization. Since the function of a cortical area requires a well-tuned receptor balance, the densities of 15 different receptors were measured in each IPL area. A hierarchical cluster analysis of the receptor balance revealed a tripartite segregation of the IPL into a rostral, middle, and caudal group. Comparison with other cortical areas showed strong similarities with Broca's region for all 3 groups, with the superior parietal cortex for the middle, and with extrastriate visual areas for the caudal group. Notably, caudal-most area PGp has a receptor fingerprint very similar to that of ventral extrastriate visual cortex. We therefore propose a new organizational model of the human IPL, consisting of 3 clusters, which corresponds to its known cytoarchitectonic, connectional, and functional diversity at the molecular level. This might reflect a general organizational principle of human IPL, beyond specific functional domains.
LB  - PUB:(DE-HGF)16
C6  - pmid:22375016
UR  - <Go to ISI:>//WOS:000316275400012
DO  - DOI:10.1093/cercor/bhs048
UR  - https://juser.fz-juelich.de/record/20245
ER  -