TY  - JOUR
AU  - Kondrat, Svyatoslav
AU  - Zimmermann, Olav
AU  - Wiechert, Wolfgang
AU  - Lieres, Eric von
TI  - The effect of composition on Diffusion of macromolecules in a crowded environment
JO  - Physical biology
VL  - 12
IS  - 4
SN  - 1478-3975
CY  - Philadelphia, Pa.
PB  - IOP Publ.
M1  - FZJ-2015-04887
SP  - 046003 -
PY  - 2015
AB  - We study diffusion of macromolecules in a crowded cytoplasm-like environment, focusing on its dependence on composition and its crossover to the anomalous subdiffusion. The crossover and the diffusion itself depend on both the volume fraction and the relative concentration of macromolecules. In accordance with previous theoretical and experimental studies, diffusion slows down when the volume fraction increases. Contrary to expectations, however, the diffusion is also strongly dependent on the molecular composition. The crossover time decreases and diffusion slows down when the smaller macromolecules start to dominate. Interestingly, diffusion is faster in a cytoplasm-like (more polydisperse) system than it is in a two-component system, at comparable packing fractions, or even when the cytoplasm packing fraction is larger.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000361837200011
DO  - DOI:10.1088/1478-3975/12/4/046003
UR  - https://juser.fz-juelich.de/record/202703
ER  -