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@ARTICLE{CastilloMelen:202869,
      author       = {Castillo Meleán, Johnny and Ermert, Johannes and Coenen,
                      Heinrich Hubert},
      title        = {{A} three-step radiosynthesis of 6-[ 18  {F}]fluoro-
                      {L}-meta -tyrosine starting with [ 18  {F}]fluoride},
      journal      = {Journal of labelled compounds and radiopharmaceuticals},
      volume       = {58},
      number       = {3},
      issn         = {0362-4803},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2015-05017},
      pages        = {133 - 140},
      year         = {2015},
      abstract     = {The radiosynthesis of 6-[18 F]fluoro-L-m-tyrosine has
                      generally been performed by electrophilic radiofluorination,
                      which exhibits several drawbacks. In the present work, a
                      three-step radiochemical synthesis is described starting
                      from [18 F]fluoride. The synthetic sequence, including
                      isotopic exchange, Baeyer–Villiger oxidation, and
                      hydrolysis, were examined comparing four fluorobenzophenone
                      derivatives as labeling precursors. Of those,
                      (2S,5S)-tert-butyl
                      5-(5-acetyl-2-fluorobenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate
                      (1a) and (2S,5S)-tert-butyl
                      2-tert-butyl-5-(2-fluoro-5-(2,2,2-trifluoroacetyl)benzyl)-3-methyl-4-oxoimidazolidine-1-carboxylate
                      (1d) proved to be the most suitable ones.
                      6-[18 F]Fluoro-L-m-tyrosine was obtained with overall
                      radiochemical yields of $8–13\%$ and an enantiomeric
                      excess of up to $98\%.$},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351764300010},
      doi          = {10.1002/jlcr.3273},
      url          = {https://juser.fz-juelich.de/record/202869},
}