Gast ::
| Hauptseite > Publikationsdatenbank > A three-step radiosynthesis of 6-[ 18 F]fluoro- L-meta -tyrosine starting with [ 18 F]fluoride > print |
| Hauptseite > Publikationsdatenbank > A three-step radiosynthesis of 6-[ 18 F]fluoro- L-meta -tyrosine starting with [ 18 F]fluoride > print |
| 001 | 202869 | ||
| 005 | 20210129220241.0 | ||
| 024 | 7 | _ | |a 10.1002/jlcr.3273 |2 doi |
| 024 | 7 | _ | |a 0022-2135 |2 ISSN |
| 024 | 7 | _ | |a 0362-4803 |2 ISSN |
| 024 | 7 | _ | |a 1099-1344 |2 ISSN |
| 024 | 7 | _ | |a WOS:000351764300010 |2 WOS |
| 037 | _ | _ | |a FZJ-2015-05017 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Castillo Meleán, Johnny |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a A three-step radiosynthesis of 6-[ 18 F]fluoro- L-meta -tyrosine starting with [ 18 F]fluoride |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2015 |b Wiley |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1438323774_548 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 520 | _ | _ | |a The radiosynthesis of 6-[18 F]fluoro-L-m-tyrosine has generally been performed by electrophilic radiofluorination, which exhibits several drawbacks. In the present work, a three-step radiochemical synthesis is described starting from [18 F]fluoride. The synthetic sequence, including isotopic exchange, Baeyer–Villiger oxidation, and hydrolysis, were examined comparing four fluorobenzophenone derivatives as labeling precursors. Of those, (2S,5S)-tert-butyl 5-(5-acetyl-2-fluorobenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate (1a) and (2S,5S)-tert-butyl 2-tert-butyl-5-(2-fluoro-5-(2,2,2-trifluoroacetyl)benzyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (1d) proved to be the most suitable ones. 6-[18 F]Fluoro-L-m-tyrosine was obtained with overall radiochemical yields of 8–13% and an enantiomeric excess of up to 98%. |
| 536 | _ | _ | |a 573 - Neuroimaging (POF3-573) |0 G:(DE-HGF)POF3-573 |c POF3-573 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Ermert, Johannes |0 P:(DE-Juel1)131818 |b 1 |e Corresponding author |u fzj |
| 700 | 1 | _ | |a Coenen, Heinrich Hubert |0 P:(DE-Juel1)131816 |b 2 |u fzj |
| 773 | _ | _ | |a 10.1002/jlcr.3273 |g Vol. 58, no. 3, p. 133 - 140 |0 PERI:(DE-600)1491841-9 |n 3 |p 133 - 140 |t Journal of labelled compounds and radiopharmaceuticals |v 58 |y 2015 |x 0362-4803 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.gif?subformat=icon |x icon |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.jpg?subformat=icon-1440 |x icon-1440 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.jpg?subformat=icon-180 |x icon-180 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.jpg?subformat=icon-640 |x icon-640 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/202869/files/Melen_et_al-2015-Journal_of_Labelled_Compounds_and_Radiopharmaceuticals.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:202869 |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)131818 |
| 910 | 1 | _ | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)131816 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-573 |2 G:(DE-HGF)POF3-500 |v Neuroimaging |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2015 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J LABELLED COMPD RAD : 2013 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-5-20090406 |k INM-5 |l Nuklearchemie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-5-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|