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| 001 | 202869 | ||
| 005 | 20210129220241.0 | ||
| 024 | 7 | _ | |a 10.1002/jlcr.3273 |2 doi |
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| 100 | 1 | _ | |a Castillo Meleán, Johnny |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a A three-step radiosynthesis of 6-[ 18 F]fluoro- L-meta -tyrosine starting with [ 18 F]fluoride |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2015 |b Wiley |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1438323774_548 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a The radiosynthesis of 6-[18 F]fluoro-L-m-tyrosine has generally been performed by electrophilic radiofluorination, which exhibits several drawbacks. In the present work, a three-step radiochemical synthesis is described starting from [18 F]fluoride. The synthetic sequence, including isotopic exchange, Baeyer–Villiger oxidation, and hydrolysis, were examined comparing four fluorobenzophenone derivatives as labeling precursors. Of those, (2S,5S)-tert-butyl 5-(5-acetyl-2-fluorobenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate (1a) and (2S,5S)-tert-butyl 2-tert-butyl-5-(2-fluoro-5-(2,2,2-trifluoroacetyl)benzyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (1d) proved to be the most suitable ones. 6-[18 F]Fluoro-L-m-tyrosine was obtained with overall radiochemical yields of 8–13% and an enantiomeric excess of up to 98%. |
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| 700 | 1 | _ | |a Ermert, Johannes |0 P:(DE-Juel1)131818 |b 1 |e Corresponding author |u fzj |
| 700 | 1 | _ | |a Coenen, Heinrich Hubert |0 P:(DE-Juel1)131816 |b 2 |u fzj |
| 773 | _ | _ | |a 10.1002/jlcr.3273 |g Vol. 58, no. 3, p. 133 - 140 |0 PERI:(DE-600)1491841-9 |n 3 |p 133 - 140 |t Journal of labelled compounds and radiopharmaceuticals |v 58 |y 2015 |x 0362-4803 |
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