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@ARTICLE{Miotto:202935,
      author       = {Miotto, Marco C. and Valiente-Gabioud, Ariel A. and
                      Rossetti, Giulia and Zweckstetter, Markus and Carloni, Paolo
                      and Selenko, Philipp and Griesinger, Christian and Binolfi,
                      Andres and Fernández, Claudio O.},
      title        = {{C}opper {B}inding to the {N}-{T}erminally {A}cetylated,
                      {N}aturally {O}ccurring {F}orm of {A}lpha-{S}ynuclein
                      {I}nduces {L}ocal {H}elical {F}olding},
      journal      = {Journal of the American Chemical Society},
      volume       = {137},
      number       = {20},
      issn         = {1520-5126},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2015-05061},
      pages        = {6444 - 6447},
      year         = {2015},
      abstract     = {Growing evidence supports a link between brain copper
                      homeostasis, the formation of alpha-synuclein (AS)-copper
                      complexes, and the development of Parkinson disease (PD).
                      Recently it was demonstrated that the physiological form of
                      AS is N-terminally acetylated (AcAS). Here we used NMR
                      spectroscopy to structurally characterize the interaction
                      between Cu(I) and AcAS. We found that the formation of an
                      AcAS–Cu(I) complex at the N-terminal region stabilizes
                      local conformations with α-helical secondary structure and
                      restricted motility. Our work provides new evidence into the
                      metallo-biology of PD and opens new lines of research as the
                      formation of AcAS–Cu(I) complex might impact on AcAS
                      membrane binding and aggregation.},
      cin          = {GRS / IAS-5 / JSC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)GRS-20100316 / I:(DE-Juel1)IAS-5-20120330 /
                      I:(DE-Juel1)JSC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511)},
      pid          = {G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000355383500006},
      pubmed       = {pmid:25939020},
      doi          = {10.1021/jacs.5b01911},
      url          = {https://juser.fz-juelich.de/record/202935},
}