TY  - JOUR
AU  - Kubota, Yoshiyuki
AU  - Kondo, Satoru
AU  - Nomura, Masaki
AU  - Hatada, Sayuri
AU  - Yamaguchi, Noboru
AU  - Mohamed, Alsayed A
AU  - Karube, Fuyuki
AU  - Lübke, Joachim
AU  - Kawaguchi, Yasuo
TI  - Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons
JO  - eLife
VL  - 4
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - FZJ-2015-05075
SP  - 00
PY  - 2015
AB  - Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. Serial electron micrographs (EMgs) reconstruction showed that somatic synapses were larger than dendritic contacts. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000358923700001
C6  - pmid:26142457
DO  - DOI:10.7554/eLife.07919
UR  - https://juser.fz-juelich.de/record/202957
ER  -