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@ARTICLE{Rsch:203086,
      author       = {Rösch, Sarah and Johnen, Sandra and Mazinani, Babac and
                      Müller, Frank and Pfarrer, Christiane and Walter, Peter},
      title        = {{T}he effects of iodoacetic acid on the mouse retina},
      journal      = {Graefe's archive for clinical and experimental
                      ophthalmology},
      volume       = {253},
      number       = {1},
      issn         = {1435-702X},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2015-05121},
      pages        = {25 - 35},
      year         = {2015},
      abstract     = {Background:To characterize the effects of intravitreal
                      injections of iodoacetic acid (IAA) in comparison to its
                      systemic application as a measure to induce unilateral
                      photoreceptor degeneration.Methods:Seven-week-old C57BL/6 J
                      mice received either intravitreal injections of IAA or
                      systemic treatment (intraperitoneal vs intravenous) and were
                      observed in the following 5 weeks using ERG, OCT, and
                      histology.Results:Systemic treatment with IAA induced high
                      toxic effects and a high mortality in contrast to the
                      intravitreal injection. Intraperitoneal application had no
                      effect on the retina. Intravenous application of 2 × 30
                      mg/kg BW IAA (time between injections 3.5 h) resulted in an
                      extinction of the ERG and a thinning of the retina, in
                      particular of the outer nuclear layer (ONL) indicating
                      photoreceptor degeneration. Animals receiving intravitreal
                      injections developed cataracts already at low concentrations
                      (up to 100 $\%$ at 0.25 mg/kg BW). Higher intravitreal IAA
                      doses led to extinguished ERGs. In histology, a thinning of
                      the entire retina was observed that was most prominent in
                      the inner part of the retina.Conclusions:In contrast to
                      intraperitoneal administration, intravenous application of
                      IAA led to a selective photoreceptor degeneration. After
                      intravitreal injection, dense cataracts were already
                      observed at concentrations lower than those needed to induce
                      changes in the ERG. ERG results must be interpreted
                      carefully. A thinning of all retinal layers rather than a
                      specific outer retinal degeneration was observed upon
                      intravitreal injection. IAA is not a useful model to induce
                      outer retinal degeneration in mice.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000347553200004},
      pubmed       = {pmid:24827634},
      doi          = {10.1007/s00417-014-2652-0},
      url          = {https://juser.fz-juelich.de/record/203086},
}