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| 001 | 203086 | ||
| 005 | 20210129220300.0 | ||
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| 100 | 1 | _ | |a Rösch, Sarah |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a The effects of iodoacetic acid on the mouse retina |
| 260 | _ | _ | |a Berlin |c 2015 |b Springer |
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| 520 | _ | _ | |a Background:To characterize the effects of intravitreal injections of iodoacetic acid (IAA) in comparison to its systemic application as a measure to induce unilateral photoreceptor degeneration.Methods:Seven-week-old C57BL/6 J mice received either intravitreal injections of IAA or systemic treatment (intraperitoneal vs intravenous) and were observed in the following 5 weeks using ERG, OCT, and histology.Results:Systemic treatment with IAA induced high toxic effects and a high mortality in contrast to the intravitreal injection. Intraperitoneal application had no effect on the retina. Intravenous application of 2 × 30 mg/kg BW IAA (time between injections 3.5 h) resulted in an extinction of the ERG and a thinning of the retina, in particular of the outer nuclear layer (ONL) indicating photoreceptor degeneration. Animals receiving intravitreal injections developed cataracts already at low concentrations (up to 100 % at 0.25 mg/kg BW). Higher intravitreal IAA doses led to extinguished ERGs. In histology, a thinning of the entire retina was observed that was most prominent in the inner part of the retina.Conclusions:In contrast to intraperitoneal administration, intravenous application of IAA led to a selective photoreceptor degeneration. After intravitreal injection, dense cataracts were already observed at concentrations lower than those needed to induce changes in the ERG. ERG results must be interpreted carefully. A thinning of all retinal layers rather than a specific outer retinal degeneration was observed upon intravitreal injection. IAA is not a useful model to induce outer retinal degeneration in mice. |
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| 700 | 1 | _ | |a Walter, Peter |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1007/s00417-014-2652-0 |g Vol. 253, no. 1, p. 25 - 35 |0 PERI:(DE-600)1459159-5 |n 1 |p 25 - 35 |t Graefe's archive for clinical and experimental ophthalmology |v 253 |y 2015 |x 1435-702X |
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