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@ARTICLE{Shaykhalishahi:203089,
      author       = {Shaykhalishahi, Hamed and Mirecka, Ewa A. and Gauhar, Aziz
                      and Grüning, Clara S. R. and Willbold, Dieter and Härd,
                      Torleif and Stoldt, Matthias and Hoyer, Wolfgang},
      title        = {{A} β-{H}airpin-{B}inding {P}rotein for {T}hree
                      {D}ifferent {D}isease-{R}elated {A}myloidogenic {P}roteins},
      journal      = {ChemBioChem},
      volume       = {16},
      number       = {3},
      issn         = {1439-4227},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2015-05124},
      pages        = {411 - 414},
      year         = {2015},
      abstract     = {Amyloidogenic proteins share a propensity to convert to the
                      b-structure-rich amyloid state that is associated with the
                      progression of several protein-misfolding disorders. Here we
                      show that a single engineered b-hairpin-binding protein, the
                      bwrapin AS10, binds monomers of three different
                      amyloidogenic proteins, that is, amyloid-b peptide,
                      a-synuclein, and islet amyloid polypeptide, with
                      sub-micromolar affinity. AS10 binding inhibits the
                      aggregation and toxicity of all three proteins. The results
                      demonstrate common conformational preferences and related
                      binding sites in a subset of the amyloidogenic proteins.
                      These commonalities enable the generation of multispecific
                      monomer-binding agents.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000350136300008},
      pubmed       = {pmid:25557164},
      doi          = {10.1002/cbic.201402552},
      url          = {https://juser.fz-juelich.de/record/203089},
}