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000203215 1001_ $$0P:(DE-HGF)0$$aMarkser, A.$$b0
000203215 245__ $$aDeep brain stimulation and cognitive decline in Parkinson’s disease: The predictive value of electroencephalography
000203215 260__ $$a[Darmstadt]$$bSteinkopff$$c2015
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000203215 520__ $$aSome Parkinson’s disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) develop new-onset cognitive decline. We examined whether clinical EEG recordings can be used to predict cognitive deterioration in PD patients undergoing STN-DBS. In this retrospective study, we used the Grand Total EEG (GTE)-score (short and total) to evaluate pre- and postoperative EEGs. In PD patients undergoing STN-DBS (N = 30), cognitive functioning was measured using Mini-Mental State Test and DemTect before and after surgery. Severity of motor impairment was assessed using the Unified Parkinson’s Disease Rating Scale-III. Patients were classified into patients with or without cognitive decline after STN-DBS surgery. Epidemiological data, pre- and postoperative EEG recordings as well as neuropsychological and neurological data, electrode positions and the third ventricle width were compared. A logistic regression model was used to identify predictors of cognitive decline. Motor deficits significantly improved from pre- to post-surgery, while the mean GTE-scores increased significantly. Six patients developed cognitive deterioration 4–12 months postoperatively. These patients had significantly higher preoperative GTE-scores than patients without cognitive deterioration, although preoperative cognitive functioning was comparable. Electrode positions, brain atrophy and neurological data did not differ between groups. Logistic regression analysis identified the GTE-score as a significant predictor of postoperative cognitive deterioration. Data suggest that the preoperative GTE-score can be used to identify PD patients that are at high risk for developing cognitive deterioration after STN-DBS surgery even though their preoperative cognitive state was normal.
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000203215 7001_ $$0P:(DE-HGF)0$$aMaier, F.$$b1$$eCorresponding author
000203215 7001_ $$0P:(DE-HGF)0$$aLewis, C. J.$$b2
000203215 7001_ $$0P:(DE-HGF)0$$aDembek, T. A.$$b3
000203215 7001_ $$0P:(DE-HGF)0$$aPedrosa, D.$$b4
000203215 7001_ $$0P:(DE-HGF)0$$aEggers, C.$$b5
000203215 7001_ $$0P:(DE-HGF)0$$aTimmermann, L.$$b6
000203215 7001_ $$0P:(DE-HGF)0$$aKalbe, E.$$b7
000203215 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b8
000203215 7001_ $$0P:(DE-HGF)0$$aBurghaus, L.$$b9
000203215 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-015-7839-8$$n10$$p2275-2284$$tJournal of neurology$$v262$$x0012-1037$$y2015
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