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@ARTICLE{Markser:203215,
      author       = {Markser, A. and Maier, F. and Lewis, C. J. and Dembek, T.
                      A. and Pedrosa, D. and Eggers, C. and Timmermann, L. and
                      Kalbe, E. and Fink, Gereon Rudolf and Burghaus, L.},
      title        = {{D}eep brain stimulation and cognitive decline in
                      {P}arkinson’s disease: {T}he predictive value of
                      electroencephalography},
      journal      = {Journal of neurology},
      volume       = {262},
      number       = {10},
      issn         = {0012-1037},
      address      = {[Darmstadt]},
      publisher    = {Steinkopff},
      reportid     = {FZJ-2015-05204},
      pages        = {2275-2284},
      year         = {2015},
      abstract     = {Some Parkinson’s disease (PD) patients treated with
                      subthalamic nucleus deep brain stimulation (STN-DBS) develop
                      new-onset cognitive decline. We examined whether clinical
                      EEG recordings can be used to predict cognitive
                      deterioration in PD patients undergoing STN-DBS. In this
                      retrospective study, we used the Grand Total EEG (GTE)-score
                      (short and total) to evaluate pre- and postoperative EEGs.
                      In PD patients undergoing STN-DBS (N = 30), cognitive
                      functioning was measured using Mini-Mental State Test and
                      DemTect before and after surgery. Severity of motor
                      impairment was assessed using the Unified Parkinson’s
                      Disease Rating Scale-III. Patients were classified into
                      patients with or without cognitive decline after STN-DBS
                      surgery. Epidemiological data, pre- and postoperative EEG
                      recordings as well as neuropsychological and neurological
                      data, electrode positions and the third ventricle width were
                      compared. A logistic regression model was used to identify
                      predictors of cognitive decline. Motor deficits
                      significantly improved from pre- to post-surgery, while the
                      mean GTE-scores increased significantly. Six patients
                      developed cognitive deterioration 4–12 months
                      postoperatively. These patients had significantly higher
                      preoperative GTE-scores than patients without cognitive
                      deterioration, although preoperative cognitive functioning
                      was comparable. Electrode positions, brain atrophy and
                      neurological data did not differ between groups. Logistic
                      regression analysis identified the GTE-score as a
                      significant predictor of postoperative cognitive
                      deterioration. Data suggest that the preoperative GTE-score
                      can be used to identify PD patients that are at high risk
                      for developing cognitive deterioration after STN-DBS surgery
                      even though their preoperative cognitive state was normal.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000363035800009},
      doi          = {10.1007/s00415-015-7839-8},
      url          = {https://juser.fz-juelich.de/record/203215},
}