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@ARTICLE{BubenzerBusch:203446,
author = {Bubenzer-Busch, S. and Herpertz-Dahlmann, B. and
Kuzmanovic, B. and Gaber, T. J. and Helmbold, K. and
Ullisch, M. G. and Baurmann, D. and Eickhoff, Simon and
Fink, G. R. and Zepf, F. D.},
title = {{N}eural correlates of reactive aggression in children with
attention-deficit/hyperactivity disorder and comorbid
disruptive behaviour disorders},
journal = {Acta psychiatrica Scandinavica},
volume = {133},
number = {4},
issn = {0001-690X},
address = {Oxford [u. a.]},
publisher = {Wiley-Blackwell},
reportid = {FZJ-2015-05382},
pages = {310-323},
year = {2016},
abstract = {ObjectiveAttention deficit hyperactivity disorder (ADHD) is
often linked with impulsive and aggressive behaviour,
indexed by high comorbidity rates between ADHD and
disruptive behaviour disorders (DBD). The present study
aimed to investigate underlying neural activity of reactive
aggression in children with ADHD and comorbid DBD using
functional neuroimaging techniques (fMRI).MethodEighteen
boys with ADHD (age 9–14 years, 10 subjects with comorbid
DBD) and 18 healthy controls were administered a modified
fMRI-based version of the ‘Point Subtraction Aggression
Game’ to elicit reactive aggressive behaviour. Trials
consisted of an ‘aggression phase’ (punishment for a
fictitious opponent) and an ‘outcome phase’
(presentation of the trial outcome).ResultsDuring the
aggression phase, higher aggressive responses of control
children were accompanied by higher activation of the
ventral anterior cingulate cortex and the temporoparietal
junction. Patients displayed inverted results. During the
outcome phase, comparison between groups and conditions
showed differential activation in the dorsal striatum and
bilateral insular when subjects gained points. Losing points
was accompanied by differential activation of regions
belonging to the insula and the middle temporal
sulcus.ConclusionData support the hypothesis that deficient
inhibitory control mechanisms are related to increased
impulsive aggressive behaviour in young people with ADHD and
comorbid DBD.},
cin = {INM-1 / INM-3 / INM-8},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406 /
I:(DE-Juel1)INM-8-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000372908000007},
pubmed = {pmid:26292852},
doi = {10.1111/acps.12475},
url = {https://juser.fz-juelich.de/record/203446},
}