TY  - JOUR
AU  - Schulze, T.G.
AU  - Akula, N.
AU  - Breuer, R.
AU  - Steele, J.
AU  - Nalls, M.A.
AU  - Singleton, A.B.
AU  - Degenhardt, F.A.
AU  - Nöthen, M.M.
AU  - Cichon, S.
AU  - Rietschel, M.
AU  - McMahon, F.J.
TI  - Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder
JO  - The world journal of biological psychiatry
VL  - 15
IS  - 3
SN  - 1562-2975
CY  - London [u.a.]
PB  - Informa Healthcare
M1  - PreJuSER-20390
SP  - 200-208
PY  - 2014
N1  - Record converted from VDB: 12.11.2012
AB  - Objectives. Genome-wide association studies (GWAS) in complex phenotypes, including psychiatric disorders, have yielded many replicated findings, yet individual markers account for only a small fraction of the inherited differences in risk. We tested the performance of polygenic models in discriminating between cases and healthy controls and among cases with distinct psychiatric diagnoses. Methods. GWAS results in bipolar disorder (BD), major depressive disorder (MDD), schizophrenia (SZ), and Parkinson's disease (PD) were used to assign weights to individual alleles, based on odds ratios. These weights were used to calculate allele scores for individual cases and controls in independent samples, summing across many single nucleotide polymorphisms (SNPs). How well allele scores discriminated between cases and controls and between cases with different disorders was tested by logistic regression. Results. Large sets of SNPs were needed to achieve even modest discrimination between cases and controls. The most informative SNPs were overlapping in BD, SZ, and MDD, with correlated effect sizes. Little or no overlap was seen between allele scores for psychiatric disorders and those for PD. Conclusions. BD, SZ, and MDD all share a similar polygenic component, but the polygenic models tested lack discriminative accuracy and are unlikely to be useful for clinical diagnosis.
LB  - PUB:(DE-HGF)16
C6  - pmid:22404658
C2  - pmc:PMC3406228
UR  - <Go to ISI:>//WOS:000332798400004
DO  - DOI:10.3109/15622975.2012.662282
UR  - https://juser.fz-juelich.de/record/20390
ER  -