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000020479 0247_ $$2DOI$$a10.1212/WNL.0b013e318245287d
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000020479 084__ $$2WoS$$aClinical Neurology
000020479 1001_ $$0P:(DE-Juel1)VDB105832$$aJacobs, H.I.L.$$b0$$uFZJ
000020479 245__ $$aFunctional integration of parietal lobe activity in early Alzheimer's disease
000020479 260__ $$aHagerstown, Md.$$bLippincott Williams & Wilkins$$c2012
000020479 300__ $$a352 - 360
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000020479 440_0 $$04555$$aNeurology$$v78$$x0028-3878$$y5
000020479 500__ $$aStudy funding: Supported by a grant from the FP6 EU programme Marie Curie Actions [MEST-CT-2005-020589].
000020479 520__ $$aParietal lobe dysfunction is an important characteristic of early Alzheimer disease (AD). Functional studies have shown conflicting parietal activation patterns indicative of either compensatory or dysfunctional mechanisms. This study aimed at examining activation differences in early AD using a visuospatial task. We focused on functional characteristics of the parietal lobe and examined compensation or disconnection mechanisms by combining a fMRI task with effective connectivity measures from Granger causality mapping (GCM).Eighteen male patients with amnestic mild cognitive impairment (aMCI) and 18 male cognitively healthy older individuals were given a mental rotation task with different rotation angles.There were no behavioral group differences on the fMRI task. Separate measurements at each angle revealed widespread activation group differences. More temporal and parietal activation in the higher angle condition was observed in patients with aMCI. The parametric modulation, which identifies regions associated with increasing angle, confirmed these results. The GCM showed increased connectivity within the parietal lobe and between parietal and temporal regions in patients with aMCI. Decreased connectivity was found between the inferior parietal lobule and posterior cingulate gyrus. Connectivity patterns correlated with memory performance scores in patients with aMCI.Our results demonstrate increased effective temporoparietal connectivity in patients with aMCI, while maintaining intact behavioral performance. This might be a compensational mechanism to counteract a parietal-posterior cingulate gyrus disconnection. These findings highlight the importance of connectivity changes in the pathophysiology of AD. In addition, effective connectivity may be a promising method for evaluating interventions aimed at the promotion of compensatory mechanisms.
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000020479 650_2 $$2MeSH$$aAged
000020479 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000020479 650_2 $$2MeSH$$aBrain Mapping
000020479 650_2 $$2MeSH$$aCausality
000020479 650_2 $$2MeSH$$aData Interpretation, Statistical
000020479 650_2 $$2MeSH$$aFunctional Laterality: physiology
000020479 650_2 $$2MeSH$$aHumans
000020479 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000020479 650_2 $$2MeSH$$aImagination: physiology
000020479 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000020479 650_2 $$2MeSH$$aMale
000020479 650_2 $$2MeSH$$aMiddle Aged
000020479 650_2 $$2MeSH$$aMild Cognitive Impairment: physiopathology
000020479 650_2 $$2MeSH$$aNeuropsychological Tests
000020479 650_2 $$2MeSH$$aParietal Lobe: physiopathology
000020479 650_2 $$2MeSH$$aReaction Time: physiology
000020479 650_2 $$2MeSH$$aSocioeconomic Factors
000020479 650_2 $$2MeSH$$aTemporal Lobe: physiopathology
000020479 650_7 $$2WoSType$$aJ
000020479 7001_ $$0P:(DE-HGF)0$$aVan Boxtel, M.P.J.$$b1
000020479 7001_ $$0P:(DE-HGF)0$$aHeinecke, A.$$b2
000020479 7001_ $$0P:(DE-HGF)0$$aGronenschild, E.H.B.M.$$b3
000020479 7001_ $$0P:(DE-HGF)0$$aBackes, W.H.$$b4
000020479 7001_ $$0P:(DE-HGF)0$$aJolles, J.$$b5
000020479 7001_ $$0P:(DE-HGF)0$$aVerhey, F.R.J.$$b6
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000020479 8567_ $$uhttp://dx.doi.org/10.1212/WNL.0b013e318245287d
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