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@ARTICLE{Jacobs:20479,
      author       = {Jacobs, H.I.L. and Van Boxtel, M.P.J. and Heinecke, A. and
                      Gronenschild, E.H.B.M. and Backes, W.H. and Jolles, J. and
                      Verhey, F.R.J.},
      title        = {{F}unctional integration of parietal lobe activity in early
                      {A}lzheimer's disease},
      journal      = {Neurology},
      volume       = {78},
      issn         = {0028-3878},
      address      = {Hagerstown, Md.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {PreJuSER-20479},
      pages        = {352 - 360},
      year         = {2012},
      note         = {Study funding: Supported by a grant from the FP6 EU
                      programme Marie Curie Actions [MEST-CT-2005-020589].},
      abstract     = {Parietal lobe dysfunction is an important characteristic of
                      early Alzheimer disease (AD). Functional studies have shown
                      conflicting parietal activation patterns indicative of
                      either compensatory or dysfunctional mechanisms. This study
                      aimed at examining activation differences in early AD using
                      a visuospatial task. We focused on functional
                      characteristics of the parietal lobe and examined
                      compensation or disconnection mechanisms by combining a fMRI
                      task with effective connectivity measures from Granger
                      causality mapping (GCM).Eighteen male patients with amnestic
                      mild cognitive impairment (aMCI) and 18 male cognitively
                      healthy older individuals were given a mental rotation task
                      with different rotation angles.There were no behavioral
                      group differences on the fMRI task. Separate measurements at
                      each angle revealed widespread activation group differences.
                      More temporal and parietal activation in the higher angle
                      condition was observed in patients with aMCI. The parametric
                      modulation, which identifies regions associated with
                      increasing angle, confirmed these results. The GCM showed
                      increased connectivity within the parietal lobe and between
                      parietal and temporal regions in patients with aMCI.
                      Decreased connectivity was found between the inferior
                      parietal lobule and posterior cingulate gyrus. Connectivity
                      patterns correlated with memory performance scores in
                      patients with aMCI.Our results demonstrate increased
                      effective temporoparietal connectivity in patients with
                      aMCI, while maintaining intact behavioral performance. This
                      might be a compensational mechanism to counteract a
                      parietal-posterior cingulate gyrus disconnection. These
                      findings highlight the importance of connectivity changes in
                      the pathophysiology of AD. In addition, effective
                      connectivity may be a promising method for evaluating
                      interventions aimed at the promotion of compensatory
                      mechanisms.},
      keywords     = {Aged / Alzheimer Disease: physiopathology / Brain Mapping /
                      Causality / Data Interpretation, Statistical / Functional
                      Laterality: physiology / Humans / Image Processing,
                      Computer-Assisted / Imagination: physiology / Magnetic
                      Resonance Imaging / Male / Middle Aged / Mild Cognitive
                      Impairment: physiopathology / Neuropsychological Tests /
                      Parietal Lobe: physiopathology / Reaction Time: physiology /
                      Socioeconomic Factors / Temporal Lobe: physiopathology / J
                      (WoSType)},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Clinical Neurology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22262753},
      UT           = {WOS:000300040300015},
      doi          = {10.1212/WNL.0b013e318245287d},
      url          = {https://juser.fz-juelich.de/record/20479},
}