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001     20479
005     20210129210748.0
024 7 _ |2 pmid
|a pmid:22262753
024 7 _ |2 DOI
|a 10.1212/WNL.0b013e318245287d
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037 _ _ |a PreJuSER-20479
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Clinical Neurology
100 1 _ |0 P:(DE-Juel1)VDB105832
|a Jacobs, H.I.L.
|b 0
|u FZJ
245 _ _ |a Functional integration of parietal lobe activity in early Alzheimer's disease
260 _ _ |a Hagerstown, Md.
|b Lippincott Williams & Wilkins
|c 2012
300 _ _ |a 352 - 360
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |0 4555
|a Neurology
|v 78
|x 0028-3878
|y 5
500 _ _ |a Study funding: Supported by a grant from the FP6 EU programme Marie Curie Actions [MEST-CT-2005-020589].
520 _ _ |a Parietal lobe dysfunction is an important characteristic of early Alzheimer disease (AD). Functional studies have shown conflicting parietal activation patterns indicative of either compensatory or dysfunctional mechanisms. This study aimed at examining activation differences in early AD using a visuospatial task. We focused on functional characteristics of the parietal lobe and examined compensation or disconnection mechanisms by combining a fMRI task with effective connectivity measures from Granger causality mapping (GCM).Eighteen male patients with amnestic mild cognitive impairment (aMCI) and 18 male cognitively healthy older individuals were given a mental rotation task with different rotation angles.There were no behavioral group differences on the fMRI task. Separate measurements at each angle revealed widespread activation group differences. More temporal and parietal activation in the higher angle condition was observed in patients with aMCI. The parametric modulation, which identifies regions associated with increasing angle, confirmed these results. The GCM showed increased connectivity within the parietal lobe and between parietal and temporal regions in patients with aMCI. Decreased connectivity was found between the inferior parietal lobule and posterior cingulate gyrus. Connectivity patterns correlated with memory performance scores in patients with aMCI.Our results demonstrate increased effective temporoparietal connectivity in patients with aMCI, while maintaining intact behavioral performance. This might be a compensational mechanism to counteract a parietal-posterior cingulate gyrus disconnection. These findings highlight the importance of connectivity changes in the pathophysiology of AD. In addition, effective connectivity may be a promising method for evaluating interventions aimed at the promotion of compensatory mechanisms.
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|a Funktion und Dysfunktion des Nervensystems (FUEK409)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Alzheimer Disease: physiopathology
650 _ 2 |2 MeSH
|a Brain Mapping
650 _ 2 |2 MeSH
|a Causality
650 _ 2 |2 MeSH
|a Data Interpretation, Statistical
650 _ 2 |2 MeSH
|a Functional Laterality: physiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted
650 _ 2 |2 MeSH
|a Imagination: physiology
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Mild Cognitive Impairment: physiopathology
650 _ 2 |2 MeSH
|a Neuropsychological Tests
650 _ 2 |2 MeSH
|a Parietal Lobe: physiopathology
650 _ 2 |2 MeSH
|a Reaction Time: physiology
650 _ 2 |2 MeSH
|a Socioeconomic Factors
650 _ 2 |2 MeSH
|a Temporal Lobe: physiopathology
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-HGF)0
|a Van Boxtel, M.P.J.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Heinecke, A.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Gronenschild, E.H.B.M.
|b 3
700 1 _ |0 P:(DE-HGF)0
|a Backes, W.H.
|b 4
700 1 _ |0 P:(DE-HGF)0
|a Jolles, J.
|b 5
700 1 _ |0 P:(DE-HGF)0
|a Verhey, F.R.J.
|b 6
773 _ _ |0 PERI:(DE-600)1491874-2
|a 10.1212/WNL.0b013e318245287d
|g Vol. 78, p. 352 - 360
|p 352 - 360
|q 78<352 - 360
|t Neurology
|v 78
|x 0028-3878
|y 2012
856 7 _ |u http://dx.doi.org/10.1212/WNL.0b013e318245287d
909 C O |o oai:juser.fz-juelich.de:20479
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