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000020779 084__ $$2WoS$$aPhysics, Mathematical
000020779 1001_ $$0P:(DE-Juel1)VDB95237$$aSchottdorf, M.$$b0$$uFZJ
000020779 245__ $$aFrequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes
000020779 260__ $$aCollege Park, Md.$$bAPS$$c2012
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000020779 500__ $$aThe authors thank William Claycomb for providing the cells, Rita Fricke for support with the cell culture, and Michael Pabst and Philipp Moritz for comments on the paper and support with the calculations. Manuel Schottdorf thanks Elitenetzwerk Bayern for financial support. The project is funded by the Helmholtz Young Investigator Program.
000020779 520__ $$aWe present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.
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