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@ARTICLE{Nieratschker:20790,
author = {Nieratschker, V. and Grosshans, M. and Frank, J. and
Strohmaier, J. and von der Goltz, C. and El-Maarri, O. and
Witt, S.H. and Cichon, S. and Nöthen, M.M. and Kiefer, F.
and Rietschel, M.},
title = {{E}pigenetic alteration of the dopamine transporter gene in
alcohol-dependent patients is associated with age},
journal = {Addiction biology},
volume = {19},
number = {2},
issn = {1355-6215},
address = {Hoboken, NJ [u.a.]},
publisher = {Wiley-Blackwell},
reportid = {PreJuSER-20790},
pages = {305–311},
year = {2014},
note = {Record converted from VDB: 12.11.2012},
abstract = {Chronic alcohol abuse and dependence are associated with
dysfunctional dopaminergic neurotransmission in
mesocorticolimbic circuits. Genetic and environmental
factors have been shown to modulate susceptibility to
alcohol dependence, and both may act through epigenetic
mechanisms that can modulate gene expression, e.g. DNA
methylation at CpG sites. Recent studies have suggested that
DNA methylation patterns may change over time. However, few
data are available concerning the rate of these changes in
specific genes. A recent study found that hypermethylation
of the promoter of the dopamine transporter (DAT) gene was
positively correlated with alcohol dependence and negatively
correlated with alcohol craving. The aim of the present
study was to replicate these findings in a larger sample of
alcohol-dependent patients and population-based controls
matched for age and sex. No difference in methylation level
was observed between patients and controls, and no
difference in methylation level was observed before and
after alcohol withdrawal in patients. However, patients with
more severe craving showed a trend towards lower DAT
methylation levels (P = 0.07), which is consistent with
previous findings. Furthermore, in our overall sample, DAT
methylation levels increased with age. Interestingly, a
separate analysis of patients suggested that this finding
was mainly driven by the patient group. Although the present
data do not clarify whether chronic alcohol abuse is
responsible for this phenomenon or merely enhances an
ageing-specific process, our findings suggest that
hypermethylation in alcohol-dependent patients is a
consequence, rather than a cause, of the disorder.},
cin = {INM-1},
ddc = {540},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
89571 - Connectivity and Activity (POF2-89571)},
pid = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:22506971},
UT = {WOS:000331529100017},
doi = {10.1111/j.1369-1600.2012.00459.x},
url = {https://juser.fz-juelich.de/record/20790},
}