TY  - JOUR
AU  - Funke, S.A.
AU  - Liu, H.
AU  - Sehl, T.
AU  - Bartnik, D.
AU  - Brener, O.
AU  - Nagel-Steger, L.
AU  - Wiesehan, K.
AU  - Willbold, D.
TI  - Identification and characterization of an Aß; oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer's disease
JO  - Rejuvenation research
VL  - 15
SN  - 1549-1684
CY  - Larchmont, NY
PB  - Liebert
M1  - PreJuSER-20882
SP  - 144 - 147
PY  - 2012
N1  - The authors gratefully acknowledge support from the "Helmholtz-CSC (China Scholarship Council) Junior Scientists Exchange Program" for Hongmei Liu.
AB  - A key feature of Alzheimer disease (AD) is the pathologic self-association of the amyloid-β (Aβ) peptide, leading to the formation of diffusible toxic Aβ oligomers and extracellular amyloid plaques. Next to extracellular Aβ, intraneuronal Aβ has important pathological functions in AD. Agents that specifically interfere with the oligomerization processes either outside or inside of neurons are highly desired for the elucidation of the pathologic mechanisms of AD and might even pave the way for new AD gene therapeutic approaches. Here, we characterize the Aβ binding peptide L3 and its influence on Aβ oligomerization in vitro. Preliminary studies in cell culture demonstrate that stably expressed L3 reduces cell toxicity of externally added Aβ in neuroblastoma cells.
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: therapy
KW  - Amyloid beta-Peptides: chemistry
KW  - Animals
KW  - Cell Line, Tumor
KW  - Centrifugation, Density Gradient
KW  - Disease Models, Animal
KW  - Gene Therapy: methods
KW  - Humans
KW  - Mice
KW  - Nephelometry and Turbidimetry
KW  - Neurons: metabolism
KW  - Peptides: chemistry
KW  - Sequence Analysis, DNA
KW  - Thiazoles: chemistry
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Peptides (NLM Chemicals)
KW  - Thiazoles (NLM Chemicals)
KW  - thioflavin T (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22533419
UR  - <Go to ISI:>//WOS:000303383600008
DO  - DOI:10.1089/rej.2011.1262
UR  - https://juser.fz-juelich.de/record/20882
ER  -