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@ARTICLE{Granzin:21147,
author = {Granzin, J. and Huang, Y. and Topbas, C. and Huang, W. and
Wu, Z. and Misra, S. and Hazen, S.L. and Blanton, R.E. and
Lee, X. and Weiergräber, O. H.},
title = {{T}hree-dimensional structure of a schistosome serpin
revealing an unusual configuration of the helical subdomain},
journal = {Acta crystallographica / D},
volume = {68},
issn = {0907-4449},
address = {Copenhagen},
publisher = {Munksgaard},
reportid = {PreJuSER-21147},
pages = {686 - 694},
year = {2012},
note = {JG and OHW are grateful to Georg Buldt and Dieter Willbold
for continuous generous support. XL and SH are supported by
NIH grant P01HL076491. Furthermore, excellent assistance by
Craig Ogata, the manager of the X4a beamline, and his staff
at NSLS is greatly appreciated.},
abstract = {Parasitic organisms are constantly challenged by the
defence mechanisms of their respective hosts, which often
depend on serine protease activities. Consequently, protease
inhibitors such as those belonging to the serpin superfamily
have emerged as protective elements that support the
survival of the parasites. This report describes the crystal
structure of ShSPI, a serpin from the trematode Schistosoma
haematobium. The protein is exposed on the surface of
invading cercaria as well as of adult worms, suggesting its
involvement in the parasite-host interaction. While
generally conforming to the well established serpin fold,
the structure reveals several distinctive features, mostly
concerning the helical subdomain of the protein. It is
proposed that these peculiarities are related to the unique
biological properties of a small serpin subfamily which is
conserved among pathogenic schistosomes.},
keywords = {Amino Acid Sequence / Animals / Humans / Models, Molecular
/ Molecular Sequence Data / Protein Structure, Secondary /
Protein Structure, Tertiary / Schistosoma haematobium:
chemistry / Sequence Alignment / Serpins: chemistry /
Structural Homology, Protein / Serpins (NLM Chemicals) / J
(WoSType)},
cin = {ICS-6},
ddc = {570},
cid = {I:(DE-Juel1)ICS-6-20110106},
pnm = {Funktion und Dysfunktion des Nervensystems / BioSoft:
Makromolekulare Systeme und biologische
Informationsverarbeitung},
pid = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505},
shelfmark = {Biochemical Research Methods / Biochemistry $\&$ Molecular
Biology / Biophysics / Crystallography},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:22683791},
pmc = {pmc:PMC3370883},
UT = {WOS:000305003700009},
doi = {10.1107/S0907444912008372},
url = {https://juser.fz-juelich.de/record/21147},
}