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000021271 084__ $$2WoS$$aCell Biology
000021271 1001_ $$0P:(DE-Juel1)VDB71075$$aMöhl, C.$$b0$$uFZJ
000021271 245__ $$aQuantitative Mapping of Averaged Focal Adhesion Dynamics in Migrating Cells by Shape Normalization
000021271 260__ $$aCambridge$$bCompany of Biologists Limited$$c2012
000021271 300__ $$a155 - 165
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000021271 440_0 $$025923$$aJournal of Cell Science$$v125$$y1
000021271 500__ $$aThis work was supported by the Bundesministerium fur Bildung und Forschung (BMBF) program [grant number 0315501].
000021271 520__ $$aThe spatially ordered formation and disassembly of focal adhesions is a basic requirement for effective cell locomotion. Because focal adhesions couple the contractile actin-myosin network to the substrate, their distribution determines the pattern of traction forces propelling the cell in a certain direction. In the present study, we quantitatively analyzed the spatial patterning of cell-substrate adhesion in migrating cells by mapping averaged focal adhesion growth dynamics to a standardized cell coordinate system. These maps revealed distinct zones of focal adhesion assembly, disassembly and stability and were strongly interrelated with corresponding actin flow and traction force patterns. Moreover, the mapping technique enables precise detection of even minute responses of adhesion dynamics upon targeted signaling perturbations. For example, the partial inhibition of vinculin phosphorylation was followed by the reduced number of newly formed adhesions, whereas growth dynamics of existing adhesions remained unaffected.
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000021271 65320 $$2Author$$aActin flow
000021271 65320 $$2Author$$aCell migration
000021271 65320 $$2Author$$aFocal adhesion dynamics
000021271 65320 $$2Author$$aTraction force
000021271 650_7 $$2WoSType$$aJ
000021271 7001_ $$0P:(DE-Juel1)VDB8902$$aKirchgeßner, N.$$b1$$uFZJ
000021271 7001_ $$0P:(DE-Juel1)VDB8500$$aSchäfer, C.$$b2$$uFZJ
000021271 7001_ $$0P:(DE-Juel1)VDB27696$$aHoffmann, B.$$b3$$uFZJ
000021271 7001_ $$0P:(DE-Juel1)128833$$aMerkel, R.$$b4$$uFZJ
000021271 773__ $$0PERI:(DE-600)1483099-1$$a10.1242/jcs.090746$$gVol. 125, p. 155 - 165$$p155 - 165$$q125<155 - 165$$tJournal of cell science$$v125$$x0021-9533$$y2012
000021271 8567_ $$uhttp://dx.doi.org/10.1242/jcs.090746
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