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@ARTICLE{Mhl:21271,
      author       = {Möhl, C. and Kirchgeßner, N. and Schäfer, C. and
                      Hoffmann, B. and Merkel, R.},
      title        = {{Q}uantitative {M}apping of {A}veraged {F}ocal {A}dhesion
                      {D}ynamics in {M}igrating {C}ells by {S}hape
                      {N}ormalization},
      journal      = {Journal of cell science},
      volume       = {125},
      issn         = {0021-9533},
      address      = {Cambridge},
      publisher    = {Company of Biologists Limited},
      reportid     = {PreJuSER-21271},
      pages        = {155 - 165},
      year         = {2012},
      note         = {This work was supported by the Bundesministerium fur
                      Bildung und Forschung (BMBF) program [grant number
                      0315501].},
      abstract     = {The spatially ordered formation and disassembly of focal
                      adhesions is a basic requirement for effective cell
                      locomotion. Because focal adhesions couple the contractile
                      actin-myosin network to the substrate, their distribution
                      determines the pattern of traction forces propelling the
                      cell in a certain direction. In the present study, we
                      quantitatively analyzed the spatial patterning of
                      cell-substrate adhesion in migrating cells by mapping
                      averaged focal adhesion growth dynamics to a standardized
                      cell coordinate system. These maps revealed distinct zones
                      of focal adhesion assembly, disassembly and stability and
                      were strongly interrelated with corresponding actin flow and
                      traction force patterns. Moreover, the mapping technique
                      enables precise detection of even minute responses of
                      adhesion dynamics upon targeted signaling perturbations. For
                      example, the partial inhibition of vinculin phosphorylation
                      was followed by the reduced number of newly formed
                      adhesions, whereas growth dynamics of existing adhesions
                      remained unaffected.},
      keywords     = {J (WoSType)},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      shelfmark    = {Cell Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22250204},
      UT           = {WOS:000300329100015},
      doi          = {10.1242/jcs.090746},
      url          = {https://juser.fz-juelich.de/record/21271},
}