Hauptseite > Publikationsdatenbank > Quantitative Mapping of Averaged Focal Adhesion Dynamics in Migrating Cells by Shape Normalization > print

001     21271
005     20200423203231.0
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024 7 _ |a 10.1242/jcs.090746
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082 _ _ |a 570
084 _ _ |2 WoS
|a Cell Biology
100 1 _ |0 P:(DE-Juel1)VDB71075
|a Möhl, C.
|b 0
|u FZJ
245 _ _ |a Quantitative Mapping of Averaged Focal Adhesion Dynamics in Migrating Cells by Shape Normalization
260 _ _ |a Cambridge
|b Company of Biologists Limited
|c 2012
300 _ _ |a 155 - 165
336 7 _ |a Journal Article
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440 _ 0 |0 25923
|a Journal of Cell Science
|v 125
|y 1
500 _ _ |a This work was supported by the Bundesministerium fur Bildung und Forschung (BMBF) program [grant number 0315501].
520 _ _ |a The spatially ordered formation and disassembly of focal adhesions is a basic requirement for effective cell locomotion. Because focal adhesions couple the contractile actin-myosin network to the substrate, their distribution determines the pattern of traction forces propelling the cell in a certain direction. In the present study, we quantitatively analyzed the spatial patterning of cell-substrate adhesion in migrating cells by mapping averaged focal adhesion growth dynamics to a standardized cell coordinate system. These maps revealed distinct zones of focal adhesion assembly, disassembly and stability and were strongly interrelated with corresponding actin flow and traction force patterns. Moreover, the mapping technique enables precise detection of even minute responses of adhesion dynamics upon targeted signaling perturbations. For example, the partial inhibition of vinculin phosphorylation was followed by the reduced number of newly formed adhesions, whereas growth dynamics of existing adhesions remained unaffected.
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653 2 0 |2 Author
|a Actin flow
653 2 0 |2 Author
|a Cell migration
653 2 0 |2 Author
|a Focal adhesion dynamics
653 2 0 |2 Author
|a Traction force
700 1 _ |0 P:(DE-Juel1)VDB8902
|a Kirchgeßner, N.
|b 1
|u FZJ
700 1 _ |0 P:(DE-Juel1)VDB8500
|a Schäfer, C.
|b 2
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700 1 _ |0 P:(DE-Juel1)VDB27696
|a Hoffmann, B.
|b 3
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700 1 _ |0 P:(DE-Juel1)128833
|a Merkel, R.
|b 4
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773 _ _ |0 PERI:(DE-600)1483099-1
|a 10.1242/jcs.090746
|g Vol. 125, p. 155 - 165
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|t Journal of cell science
|v 125
|x 0021-9533
|y 2012
856 7 _ |u http://dx.doi.org/10.1242/jcs.090746
856 4 _ |u https://juser.fz-juelich.de/record/21271/files/155.full.pdf
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