TY  - JOUR
AU  - Dovern, A.
AU  - Fink, G.R.
AU  - Fromme, A.
AU  - Wohlschlaeger, A.
AU  - Weiss, P.H.
TI  - Intrinsic network connectivity reflects consistency of synesthetic experiences
JO  - The journal of neuroscience
VL  - 32
SN  - 0270-6474
CY  - Washington, DC
PB  - Soc.
M1  - PreJuSER-21471
SP  - 7614 - 7621
PY  - 2012
N1  - This work was supported by Grant 8762754 of the Kommission fuer Klinische Forschung at the Klinikum Rechts der Isar (to V. R.). We are grateful to our subjects and our colleagues at the Institute of Neurocience and Medicine, Research Centre Julich.
AB  - Studying cognitive processes underlying synesthesia, a condition in which stimulation of one sensory modality automatically leads to abnormal additional sensory perception, allows insights into the neural mechanisms of normal and abnormal cross-modal sensory processing. Consistent with the notion that synesthesia results from hyperconnectivity, functional connectivity analysis (adopting independent component analysis and seed-based correlation analysis) of resting-state functional magnetic resonance imaging data of 12 grapheme-color synesthetes and 12 nonsynesthetic control subjects revealed, in addition to increased intranetwork connectivity, both a global and a specific (medial and lateral visual networks to a right frontoparietal network) increase of intrinsic internetwork connectivity in grapheme-color synesthesia. Moreover, this increased intrinsic network connectivity reflected the strength of synesthetic experiences. These findings constitute the first direct evidence of increased functional network connectivity in synesthesia. In addition to this significant contribution to the understanding of the neural mechanisms of synesthesia, our results have important general implications. In combination with data derived from clinical populations, our data strongly suggest that altered differences in intrinsic network connectivity are directly related to the phenomenology of human experiences.
KW  - Adult
KW  - Analysis of Variance
KW  - Auditory Perception: physiology
KW  - Brain: blood supply
KW  - Brain: pathology
KW  - Brain Mapping
KW  - Color Perception
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Neural Pathways: blood supply
KW  - Neural Pathways: pathology
KW  - Oxygen: blood
KW  - Perceptual Disorders: pathology
KW  - Phonetics
KW  - Regression Analysis
KW  - Rest
KW  - Young Adult
KW  - Oxygen (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22649240
UR  - <Go to ISI:>//WOS:000304627100020
DO  - DOI:10.1523/JNEUROSCI.5401-11.2012
UR  - https://juser.fz-juelich.de/record/21471
ER  -