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001     21683
005     20240619092100.0
024 7 _ |2 DOI
|a 10.1039/C2SM25665G
024 7 _ |2 WOS
|a WOS:000305481000021
024 7 _ |2 Handle
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|a C2SM25665G
037 _ _ |a PreJuSER-21683
041 _ _ |a eng
082 _ _ |a 530
084 _ _ |2 WoS
|a Chemistry, Physical
084 _ _ |2 WoS
|a Materials Science, Multidisciplinary
084 _ _ |2 WoS
|a Physics, Multidisciplinary
084 _ _ |2 WoS
|a Polymer Science
100 1 _ |0 P:(DE-HGF)0
|a Pabst, G.
|b 0
245 _ _ |a Stalk-free membrane fusion of cationic lipids via an interdigitated phase
260 _ _ |a Cambridge
|b Royal Society of Chemistry (RSC)
|c 2012
300 _ _ |a 3243 - 3249
336 7 _ |a Journal Article
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440 _ 0 |0 16881
|a Soft Matter
|v 27
|x 1744-683X
|y 8
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a We have studied the membrane structure of a cationic lipid (N-t-butyl-N'-tetradecyl-3-tetradecylaminopropionamidine, termed diC14-amidine) using X-ray and neutron small-angle scattering as well as dilatometry and ultrasound velocimetry. At high temperatures we found an anomalously thin lamellar fluid phase, which transforms into a loosely packed interdigitated phase below the chain melting transition. Our finding can be understood based on the specific structure of the lipid backbone, which forms a long spacer between the alkyl chains. The loose lipid packing in the gel phase leads to a significant exposure of the hydrophobic lipid core to the aqueous phase. This reduces energy penalties from the removal of water molecules during fusion and explains the untypically increased fusion properties of amidine in the gel phase. Moreover, this fusion in the gel interdigitated state apparently does not require the formation of stalk intermediate structures.
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650 2 7 |a Soft Condensed Matter
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650 1 7 |a Polymers, Soft Nano Particles and Proteins
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700 1 _ |0 P:(DE-HGF)0
|a Lonez, C.
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|a Vandenbranden, M.
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|a Jestin, J.
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|a Radulescu, A.
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|a Ruysschaert, J.-M.
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|a Gutberlet, T.
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|a 10.1039/c2sm25665g
|g Vol. 8, p. 3243 - 3249
|p 3243 - 3249
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|t Soft matter
|v 8
|x 1744-683X
|y 2012
856 7 _ |u http://dx.doi.org/10.1039/C2SM25665G
856 4 _ |u https://juser.fz-juelich.de/record/21683/files/FZJ-21683.pdf
|y Published under German "Allianz" Licensing conditions on 2012-06-11. Available in OpenAccess from 2013-06-11
|z Published final document.
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