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000021884 084__ $$2WoS$$aGeriatrics & Gerontology
000021884 084__ $$2WoS$$aNeurosciences
000021884 1001_ $$0P:(DE-HGF)0$$aPiefke, M.$$b0
000021884 245__ $$aAging-related changes of neural mechanisms underlying visual-spatial working memory
000021884 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2012
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000021884 440_0 $$017821$$aNeurobiology of Aging$$v33$$x0197-4580$$y7
000021884 500__ $$aM.P. is supported by the Deutsche Forschungsgemeinschaft (DFG; EC 277). G. R. F. was supported by the Bundesministerium fur Bildung und Forschung (BMBF; FKZ 01GO0509). We thank our colleagues in the MR and Cognitive Neurology groups at the Institute of Neuroscience and Medicine (Research Centre Julich) for their support and helpful advice.
000021884 520__ $$aCapacities of the prefrontal cortex (PFC) such as working memory (WM) are known to decline with increasing age. However, it is unclear which neurofunctional mechanisms may underlie this aging-related cognitive decline. The finding that PFC activity tends to be less lateralized in older subjects has led to the assumption of a hemispheric asymmetry reduction in the PFC associated with aging (HAROLD). Using functional magnetic resonance imaging (fMRI), we here investigated aging-related neurofunctional alterations during the performance of a visual-spatial WM task with differential levels of difficulty. Older volunteers activated dorsolateral PFC regions bilaterally while young subjects recruited these areas only in the left hemisphere. These data corroborate the hemispheric asymmetry reduction in the PFC associated with aging (HAROLD) account. However, we also observed functional reorganizations in parieto-occipital areas, and with increasing WM demands, an aging-related reversed hemispheric asymmetry of prefrontal activations. Importantly, neither PFC nor parieto-occipital reorganizations prevented older participants from showing worse WM performance than young volunteers. We conclude that frontal-parietal functional reorganizations may reflect compensational mechanisms related to aging, but do not obviate diminished visual-spatial WM performance in older people.
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000021884 65320 $$2Author$$aPrefrontal cortex
000021884 65320 $$2Author$$aExecutive functions
000021884 65320 $$2Author$$aVisual-spatial attention
000021884 65320 $$2Author$$aParietal cortex
000021884 65320 $$2Author$$aBiological aging
000021884 65320 $$2Author$$afMRI
000021884 650_7 $$2WoSType$$aJ
000021884 7001_ $$0P:(DE-Juel1)131736$$aOnur, Ö.A.$$b1$$uFZJ
000021884 7001_ $$0P:(DE-Juel1)131720$$aFink, G.R.$$b2$$uFZJ
000021884 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2010.10.014$$gVol. 33, p. 1284 - 1297$$p1284 - 1297$$q33<1284 - 1297$$tNeurobiology of aging$$v33$$x0197-4580$$y2012
000021884 8567_ $$uhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.10.014
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