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@ARTICLE{Piefke:21884,
      author       = {Piefke, M. and Onur, Ö.A. and Fink, G.R.},
      title        = {{A}ging-related changes of neural mechanisms underlying
                      visual-spatial working memory},
      journal      = {Neurobiology of aging},
      volume       = {33},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-21884},
      pages        = {1284 - 1297},
      year         = {2012},
      note         = {M.P. is supported by the Deutsche Forschungsgemeinschaft
                      (DFG; EC 277). G. R. F. was supported by the
                      Bundesministerium fur Bildung und Forschung (BMBF; FKZ
                      01GO0509). We thank our colleagues in the MR and Cognitive
                      Neurology groups at the Institute of Neuroscience and
                      Medicine (Research Centre Julich) for their support and
                      helpful advice.},
      abstract     = {Capacities of the prefrontal cortex (PFC) such as working
                      memory (WM) are known to decline with increasing age.
                      However, it is unclear which neurofunctional mechanisms may
                      underlie this aging-related cognitive decline. The finding
                      that PFC activity tends to be less lateralized in older
                      subjects has led to the assumption of a hemispheric
                      asymmetry reduction in the PFC associated with aging
                      (HAROLD). Using functional magnetic resonance imaging
                      (fMRI), we here investigated aging-related neurofunctional
                      alterations during the performance of a visual-spatial WM
                      task with differential levels of difficulty. Older
                      volunteers activated dorsolateral PFC regions bilaterally
                      while young subjects recruited these areas only in the left
                      hemisphere. These data corroborate the hemispheric asymmetry
                      reduction in the PFC associated with aging (HAROLD) account.
                      However, we also observed functional reorganizations in
                      parieto-occipital areas, and with increasing WM demands, an
                      aging-related reversed hemispheric asymmetry of prefrontal
                      activations. Importantly, neither PFC nor parieto-occipital
                      reorganizations prevented older participants from showing
                      worse WM performance than young volunteers. We conclude that
                      frontal-parietal functional reorganizations may reflect
                      compensational mechanisms related to aging, but do not
                      obviate diminished visual-spatial WM performance in older
                      people.},
      keywords     = {J (WoSType)},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Geriatrics $\&$ Gerontology / Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21130531},
      UT           = {WOS:000304854300019},
      doi          = {10.1016/j.neurobiolaging.2010.10.014},
      url          = {https://juser.fz-juelich.de/record/21884},
}