TY  - JOUR
AU  - Heck, A.
AU  - Tielker, D.
AU  - Ernst, J.F.
AU  - Freudl, R.
AU  - Bott, M.
AU  - Oldiges, M.
AU  - Wiechert, W.
AU  - Pietruszka, J.
AU  - Wilhelm, S.
AU  - Rosenau, F.
AU  - Drepper, T.
AU  - Jaeger, K.-E.
TI  - Expressionsoptimierung in Mikroorganismen
JO  - Biospektrum
VL  - 18
SN  - 0947-0867
CY  - Heidelberg
PB  - Spektrum
M1  - PreJuSER-21893
SP  - 449 - 451
PY  - 2012
N1  - Record converted from VDB: 12.11.2012
AB  - Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is supposed to represent an important endogenous response to tumor progression. To investigate the role of the VDR gene and its influence on 25(OH)D(3) and 1,25(OH)(2)D(3) plasma levels in thyroid carcinoma, we analyzed four VDR polymorphisms in patients and healthy controls (HC).Patients with thyroid carcinoma (n = 172) (n = 132 for papillary and n = 40 for follicular) and HC (n = 321) were genotyped for the ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410), and FokI (rs10735810) polymorphisms within the VDR gene and correlated with 25(OH)D(3) and 1,25(OH)(2)D(3) plasma levels.The genotypes AA of the ApaI (rs7975232) and FF of the FokI (rs10735810) polymorphisms were significantly less frequent (12.5% vs. 35.2% and 25% vs. 42.1%, respectively, both corrected p [p(c)] = 0.04) in patients with follicular thyroid cancer (FTC) than in HC. Additionally, the haplotypes, Ta (57.5% vs. 41.4%; p(c) = 0.0207), af (24.6% vs. 14.3%; p(c) = 0.0116), Tab (51.1% vs. 36.8%; p(c) = 0.0495), and Tabf (18.7% vs. 13.6%; p(c) = 0.0240) were more frequent, whereas the haplotypes AF (17.1% vs. 37.2%; p(c) = 0.0008), BF (11.4% vs. 31.9%; p(c) = 0.012), tF (7.9% vs. 25.5%; p(c) = 0.0016), and tABF (7.6% vs. 23%; p(c) = 0.0115) were less frequent in the FTC patients compared to HC. Neither genotype nor haplotype frequencies differed between patients with papillary thyroid cancer (PTC) and HC. Further, individuals with PTC and FTC had a significantly lower level of circulating 1,25(OH)(2)D(3) compared to controls. In contrast, no differences of the 25(OH)D(3) concentration between patients and HC were observed. VDR polymorphisms were not associated with 25(OH)D(3) and 1,25(OH)(2)D(3) plasma levels.Lower circulating levels of 1,25(OH)(2)D(3) are observed in patients with differentiated thyroid carcinoma. Further, while the alleles AA and FF of the ApaI (rs7975232) and FokI (rs10735810) VDR polymorphisms and the haplotype tABF confer to protection from follicular carcinoma, the haplotype Tabf appeared to be associated with an increased FTC risk. Since this is the first report associating VDR polymorphisms with thyroid carcinoma, these findings need to be confirmed in studies with larger numbers of patients.
KW  - Autoantibodies: immunology
KW  - Calcifediol: metabolism
KW  - Calcitriol: metabolism
KW  - Carcinoma, Papillary, Follicular: genetics
KW  - Carcinoma, Papillary, Follicular: pathology
KW  - Cell Differentiation
KW  - Female
KW  - Genotype
KW  - Haplotypes
KW  - Humans
KW  - Male
KW  - Neutrophil Infiltration
KW  - Polymorphism, Genetic: genetics
KW  - Receptors, Calcitriol: genetics
KW  - Thyroid Gland: immunology
KW  - Thyroid Neoplasms: genetics
KW  - Thyroid Neoplasms: pathology
KW  - Vitamin D: physiology
KW  - Autoantibodies (NLM Chemicals)
KW  - Receptors, Calcitriol (NLM Chemicals)
KW  - Vitamin D (NLM Chemicals)
KW  - Calcifediol (NLM Chemicals)
KW  - Calcitriol (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:19499989
DO  - DOI:10.1007/s12268-012-0207-7
UR  - https://juser.fz-juelich.de/record/21893
ER  -