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@ARTICLE{Keers:21918,
      author       = {Keers, R. and Pedroso, I. and Breen, G. and Aitchison, K.J.
                      and Nolan, P.M. and Cichon, S. and Nöthen, M.M. and
                      Rietschel, M. and Schalkwyk, L.C. and Fernandes, C.},
      title        = {{R}educed {A}nxiety and {D}epression-{L}ike {B}ehaviours in
                      the {C}ircadian {P}eriod {M}utant {M}ouse {A}fterhours},
      journal      = {PLoS one},
      volume       = {7},
      number       = {6},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {PreJuSER-21918},
      pages        = {e38263},
      year         = {2012},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Disruption of the circadian rhythm is a key feature of
                      bipolar disorder. Variation in genes encoding components of
                      the molecular circadian clock has been associated with
                      increased risk of the disorder in clinical populations.
                      Similarly in animal models, disruption of the circadian
                      clock can result in altered mood and anxiety which resemble
                      features of human mania; including hyperactivity, reduced
                      anxiety and reduced depression-like behaviour. One such
                      mutant, after hours (Afh), an ENU-derived mutant with a
                      mutation in a recently identified circadian clock gene
                      Fbxl3, results in a disturbed (long) circadian rhythm of
                      approximately 27 hours.Anxiety, exploratory and
                      depression-like behaviours were evaluated in Afh mice using
                      the open-field, elevated plus maze, light-dark box,
                      holeboard and forced swim test. To further validate findings
                      for human mania, polymorphisms in the human homologue of
                      FBXL3, genotyped by three genome wide case control studies,
                      were tested for association with bipolar disorder.Afh mice
                      showed reduced anxiety- and depression-like behaviour in all
                      of the behavioural tests employed, and some evidence of
                      increased locomotor activity in some tests. An analysis of
                      three separate human data sets revealed a gene wide
                      association between variation in FBXL3 and bipolar disorder
                      (P = 0.009).Our results are consistent with previous studies
                      of mutants with extended circadian periods and suggest that
                      disruption of FBXL3 is associated with mania-like behaviours
                      in both mice and humans.},
      keywords     = {J (WoSType)},
      cin          = {INM-1},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22719873},
      pmc          = {pmc:PMC3376117},
      UT           = {WOS:000305350000012},
      doi          = {10.1371/journal.pone.0038263},
      url          = {https://juser.fz-juelich.de/record/21918},
}