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000021951 0247_ $$2DOI$$a10.1002/elps.201100683
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000021951 084__ $$2WoS$$aBiochemical Research Methods
000021951 084__ $$2WoS$$aChemistry, Analytical
000021951 1001_ $$0P:(DE-HGF)0$$aRoscher, J.$$b0
000021951 245__ $$aForensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry
000021951 260__ $$aWeinheim$$bWiley-Blackwell$$c2012
000021951 300__ $$a1567 - 1570
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000021951 440_0 $$01792$$aElectrophoresis$$v33$$x0173-0835$$y11
000021951 500__ $$3POF3_Assignment on 2016-02-29
000021951 500__ $$aWe thank the Helmholtz Initiative and Networking Fund for financial support.
000021951 520__ $$aThe consumption of legal and illegal drugs follows an organic trend comparable to the current trend in food consumption. The investigation of such drugs is therefore of interest to characterize the active ingredients of plants and drug preparations. A new method of nonaqueous capillary electrophoresis coupled to mass spectrometry (NACE-MS) as a powerful tool for the separation of complex alkaloid mixtures in difficult matrices is presented in this study for the analysis of samples of Sceletium tortuosum and drug products called Kanna made thereof. The method was found to be suitable for the investigation of the alkaloid composition and relative quantification of the ingredients. It proved of value to separate a large number of isobaric compounds, most probably including diastereomers, double-bond isomers, and further structurally closely related compounds. A comparison of plant samples from different vendors, self-fermented samples, and products ready for consumption was made. The high separation power obtained allowed a better description of the chemotypic differences of plant samples as well as Kanna preparations compared to other methods presented in the literature so far. Thus, the use of the NACE-MS enables a new perspective on the alkaloid profile of Sceletium species.
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000021951 650_2 $$2MeSH$$aElectrophoresis, Capillary: methods
000021951 650_2 $$2MeSH$$aFermentation
000021951 650_2 $$2MeSH$$aForensic Sciences
000021951 650_2 $$2MeSH$$aIndole Alkaloids: analysis
000021951 650_2 $$2MeSH$$aIndole Alkaloids: chemistry
000021951 650_2 $$2MeSH$$aIndole Alkaloids: isolation & purification
000021951 650_2 $$2MeSH$$aMass Spectrometry: methods
000021951 650_2 $$2MeSH$$aMesembryanthemum: chemistry
000021951 650_2 $$2MeSH$$aPlant Extracts: analysis
000021951 650_2 $$2MeSH$$aPlant Extracts: chemistry
000021951 650_2 $$2MeSH$$aPlant Extracts: isolation & purification
000021951 650_2 $$2MeSH$$aStreet Drugs: chemistry
000021951 650_7 $$00$$2NLM Chemicals$$aIndole Alkaloids
000021951 650_7 $$00$$2NLM Chemicals$$aPlant Extracts
000021951 650_7 $$00$$2NLM Chemicals$$aStreet Drugs
000021951 650_7 $$0468-53-1$$2NLM Chemicals$$amesembrine
000021951 650_7 $$2WoSType$$aJ
000021951 65320 $$2Author$$aKanna
000021951 65320 $$2Author$$aMesembrine alkaloids
000021951 65320 $$2Author$$aNon aqueous capillary electrophoresis
000021951 65320 $$2Author$$aRecreational drugs
000021951 65320 $$2Author$$aStructural isomers
000021951 7001_ $$0P:(DE-Juel1)VDB94855$$aPosch, T.N.$$b1$$uFZJ
000021951 7001_ $$0P:(DE-HGF)0$$aPütz, M.$$b2
000021951 7001_ $$0P:(DE-Juel1)VDB93008$$aHuhn, C.$$b3$$uFZJ
000021951 773__ $$0PERI:(DE-600)1475486-1$$a10.1002/elps.201100683$$gVol. 33, p. 1567 - 1570$$p1567 - 1570$$q33<1567 - 1570$$tElectrophoresis$$v33$$x0173-0835$$y2012
000021951 8567_ $$uhttp://dx.doi.org/10.1002/elps.201100683
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