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@ARTICLE{Roscher:21951,
      author       = {Roscher, J. and Posch, T.N. and Pütz, M. and Huhn, C.},
      title        = {{F}orensic analysis of mesembrine alkaloids in {S}celetium
                      tortuosum by nonaqueous capillary electrophoresis mass
                      spectrometry},
      journal      = {Electrophoresis},
      volume       = {33},
      issn         = {0173-0835},
      address      = {Weinheim},
      publisher    = {Wiley-Blackwell},
      reportid     = {PreJuSER-21951},
      pages        = {1567 - 1570},
      year         = {2012},
      note         = {We thank the Helmholtz Initiative and Networking Fund for
                      financial support.},
      abstract     = {The consumption of legal and illegal drugs follows an
                      organic trend comparable to the current trend in food
                      consumption. The investigation of such drugs is therefore of
                      interest to characterize the active ingredients of plants
                      and drug preparations. A new method of nonaqueous capillary
                      electrophoresis coupled to mass spectrometry (NACE-MS) as a
                      powerful tool for the separation of complex alkaloid
                      mixtures in difficult matrices is presented in this study
                      for the analysis of samples of Sceletium tortuosum and drug
                      products called Kanna made thereof. The method was found to
                      be suitable for the investigation of the alkaloid
                      composition and relative quantification of the ingredients.
                      It proved of value to separate a large number of isobaric
                      compounds, most probably including diastereomers,
                      double-bond isomers, and further structurally closely
                      related compounds. A comparison of plant samples from
                      different vendors, self-fermented samples, and products
                      ready for consumption was made. The high separation power
                      obtained allowed a better description of the chemotypic
                      differences of plant samples as well as Kanna preparations
                      compared to other methods presented in the literature so
                      far. Thus, the use of the NACE-MS enables a new perspective
                      on the alkaloid profile of Sceletium species.},
      keywords     = {Electrophoresis, Capillary: methods / Fermentation /
                      Forensic Sciences / Indole Alkaloids: analysis / Indole
                      Alkaloids: chemistry / Indole Alkaloids: isolation $\&$
                      purification / Mass Spectrometry: methods /
                      Mesembryanthemum: chemistry / Plant Extracts: analysis /
                      Plant Extracts: chemistry / Plant Extracts: isolation $\&$
                      purification / Street Drugs: chemistry / Indole Alkaloids
                      (NLM Chemicals) / Plant Extracts (NLM Chemicals) / Street
                      Drugs (NLM Chemicals) / mesembrine (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ZCH},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ZCH-20090406},
      pnm          = {Techniken, Innovation und Gesellschaft (TIG)},
      pid          = {G:(DE-Juel1)FUEK506},
      shelfmark    = {Biochemical Research Methods / Chemistry, Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22736358},
      UT           = {WOS:000305753600011},
      doi          = {10.1002/elps.201100683},
      url          = {https://juser.fz-juelich.de/record/21951},
}