Home > Publications database > Forensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry > print

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024 7 _ |2 pmid
|a pmid:22736358
024 7 _ |2 DOI
|a 10.1002/elps.201100683
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037 _ _ |a PreJuSER-21951
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemical Research Methods
084 _ _ |2 WoS
|a Chemistry, Analytical
100 1 _ |a Roscher, J.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Forensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry
260 _ _ |a Weinheim
|b Wiley-Blackwell
|c 2012
300 _ _ |a 1567 - 1570
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Electrophoresis
|x 0173-0835
|0 1792
|y 11
|v 33
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a We thank the Helmholtz Initiative and Networking Fund for financial support.
520 _ _ |a The consumption of legal and illegal drugs follows an organic trend comparable to the current trend in food consumption. The investigation of such drugs is therefore of interest to characterize the active ingredients of plants and drug preparations. A new method of nonaqueous capillary electrophoresis coupled to mass spectrometry (NACE-MS) as a powerful tool for the separation of complex alkaloid mixtures in difficult matrices is presented in this study for the analysis of samples of Sceletium tortuosum and drug products called Kanna made thereof. The method was found to be suitable for the investigation of the alkaloid composition and relative quantification of the ingredients. It proved of value to separate a large number of isobaric compounds, most probably including diastereomers, double-bond isomers, and further structurally closely related compounds. A comparison of plant samples from different vendors, self-fermented samples, and products ready for consumption was made. The high separation power obtained allowed a better description of the chemotypic differences of plant samples as well as Kanna preparations compared to other methods presented in the literature so far. Thus, the use of the NACE-MS enables a new perspective on the alkaloid profile of Sceletium species.
536 _ _ |a Techniken, Innovation und Gesellschaft (TIG)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Electrophoresis, Capillary: methods
650 _ 2 |2 MeSH
|a Fermentation
650 _ 2 |2 MeSH
|a Forensic Sciences
650 _ 2 |2 MeSH
|a Indole Alkaloids: analysis
650 _ 2 |2 MeSH
|a Indole Alkaloids: chemistry
650 _ 2 |2 MeSH
|a Indole Alkaloids: isolation & purification
650 _ 2 |2 MeSH
|a Mass Spectrometry: methods
650 _ 2 |2 MeSH
|a Mesembryanthemum: chemistry
650 _ 2 |2 MeSH
|a Plant Extracts: analysis
650 _ 2 |2 MeSH
|a Plant Extracts: chemistry
650 _ 2 |2 MeSH
|a Plant Extracts: isolation & purification
650 _ 2 |2 MeSH
|a Street Drugs: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Indole Alkaloids
650 _ 7 |0 0
|2 NLM Chemicals
|a Plant Extracts
650 _ 7 |0 0
|2 NLM Chemicals
|a Street Drugs
650 _ 7 |0 468-53-1
|2 NLM Chemicals
|a mesembrine
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a Kanna
653 2 0 |2 Author
|a Mesembrine alkaloids
653 2 0 |2 Author
|a Non aqueous capillary electrophoresis
653 2 0 |2 Author
|a Recreational drugs
653 2 0 |2 Author
|a Structural isomers
700 1 _ |a Posch, T.N.
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700 1 _ |a Pütz, M.
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700 1 _ |a Huhn, C.
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773 _ _ |a 10.1002/elps.201100683
|g Vol. 33, p. 1567 - 1570
|p 1567 - 1570
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|0 PERI:(DE-600)1475486-1
|t Electrophoresis
|v 33
|y 2012
|x 0173-0835
856 7 _ |u http://dx.doi.org/10.1002/elps.201100683
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