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@ARTICLE{Matusch:22035,
      author       = {Matusch, A. and Becker, J.S.},
      title        = {{B}io-imaging of metals in a mouse model of {A}lzheimer's
                      disease by laser ablation inductively coupled plasma mass
                      spectrometry},
      journal      = {Biomedical Spectroscopy and Imaging},
      volume       = {1},
      issn         = {2212-8794},
      address      = {Birmingham, Ala.},
      publisher    = {IOS Press},
      reportid     = {PreJuSER-22035},
      pages        = {57 - 65},
      year         = {2012},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Quantitative mass spectrometry imaging (MSI) of metals in
                      biological tissue sections by laser ablation inductively
                      coupled plasma mass spectrometry (LA-ICP-MS) using
                      matrix-matched laboratory standards has been established
                      previously. Here an improved calibration strategy is
                      proposed, correcting for variable section thickness by
                      normalization of sample and standard ion intensities to the
                      average 13C+ ion signal of all ablated sample and standard
                      material, respectively. Altered metal metabolism is known in
                      Alzheimer's disease of which amyloid precursor protein (APP)
                      transgenic mice are a popular model. Quantitative
                      distribution analysis of Fe, Zn, Cu and Mn in horizontal
                      brain sections of 45 week old Tg2576 transgenic mice showed
                      a $22\%$ decrease of Cu and changes of Fe, Zn and Mn of
                      $−1\%,$ $−7\%$ and $−17\%.$ Local evaluation across a
                      set of anatomically defined regions of interest showed an
                      increased circum-ventricular to parenchyma ratio of Cu
                      pointing to a higher Cu efflux and a heterogeneous pattern
                      of Fe changes pointing to clearance of Fe at the sites of
                      early pathology. Congruencies to synchrotron X-ray
                      fluorescence data on distinct types of APP mice are
                      discussed. MSI by LA-ICP-MS thus proved as a valuable and
                      versatile tool for studying the cerebral
                      metallo-architecture and the validation of animal models.},
      keywords     = {Adolescent / Adult / Bacteremia: epidemiology / Bacteremia:
                      microbiology / Bacteria: isolation $\&$ purification / Child
                      / Child, Preschool / Female / Gram-Negative Bacterial
                      Infections: epidemiology / Gram-Negative Bacterial
                      Infections: microbiology / Gram-Positive Bacterial
                      Infections: epidemiology / Gram-Positive Bacterial
                      Infections: microbiology / Humans / Incidence / Infant /
                      Intestine, Small: transplantation / Male / Middle Aged /
                      Postoperative Complications / Retrospective Studies / Risk
                      Factors / Time Factors / Young Adult},
      cin          = {ZCH / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22093913},
      doi          = {10.3233/BSI-2012-0005},
      url          = {https://juser.fz-juelich.de/record/22035},
}