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000022269 084__ $$2WoS$$aNeurosciences
000022269 1001_ $$0P:(DE-Juel1)131679$$aElmenhorst, D.$$b0$$uFZJ
000022269 245__ $$aTest-Retest Stability of Cerebral mGluR5 Quantification Using [11C]ABP688 and Positron Emission Tomography in Rats
000022269 260__ $$aNew York, NY$$bWiley-Liss$$c2012
000022269 300__ $$a552 - 560
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000022269 440_0 $$013481$$aSynapse$$v66$$x0887-4476$$y6
000022269 500__ $$aContract grant sponsor: Heinrich Hertz Foundation of the Ministry of Science and Technology; Contract grant sponsor: North-Rhine Westfalia, Germany; Contract grant sponsor: Alzheimer's Association new investigator award; Contract grant number: NIRG-08-92090; Contract grant sponsor: Fonds de la Recherche en Sante du Quebec (FRSQ); Contract grant sponsor: Chercheur Burcier award (PRN); Contract grant sponsor: Aisenstadt Foundation.
000022269 520__ $$aThis study evaluates the reproducibility of the quantification of metabotropic glutamate receptor type 5 (mGluR₅) densities in rats using the PET radiotracer [¹¹C]ABP688 and pharmacokinetic models that are based on an input function, which is derived from a reference tissue. Seven rats underwent dynamic PET scans (60 min) after bolus injection of [¹¹C]ABP688. Kinetic analyses included: binding potential (BP(ND) ) determined by calculating (a) the simplified reference tissue model (SRTM) and (b) its two-steps simplified version (SRTM2); (c) multilinear reference tissue model (MRTM) and (d) its 2-parameter version (MRTM2); (e) noninvasive graphical analysis (NIGA). Parametric images were generated representing BP(ND) by the MRTM2 model. BP(ND) determinations were reproducible with low to acceptable variability ranging from 5 to 10% and reproducibility scores (intraclass correlation coefficient) between 0.51 and 0.88. The pharmacokinetic model that showed lowest overall variability was the SRTM. In contrast, the use of the NIGA was associated with significantly lower reproducibility scores. Comparison of parametric images revealed no significant bias between test and retest measurements and is therefore suitable to compare groups at voxel levels. In conclusion, our results suggest that noninvasive quantification of [¹¹C]ABP688 imaging is reproducible and reliable for PET studies of the cerebral mGluR₅ in rats.
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000022269 65320 $$2Author$$apositron emission tomography
000022269 65320 $$2Author$$atest-retest
000022269 65320 $$2Author$$akinetic modeling
000022269 65320 $$2Author$$a[11C]ABP688
000022269 650_2 $$2MeSH$$aAlgorithms
000022269 650_2 $$2MeSH$$aAnimals
000022269 650_2 $$2MeSH$$aBrain: radionuclide imaging
000022269 650_2 $$2MeSH$$aBrain Chemistry
000022269 650_2 $$2MeSH$$aCarbon Radioisotopes: chemistry
000022269 650_2 $$2MeSH$$aImage Interpretation, Computer-Assisted
000022269 650_2 $$2MeSH$$aKinetics
000022269 650_2 $$2MeSH$$aMale
000022269 650_2 $$2MeSH$$aOximes: analysis
000022269 650_2 $$2MeSH$$aOximes: chemistry
000022269 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000022269 650_2 $$2MeSH$$aPyridines: analysis
000022269 650_2 $$2MeSH$$aPyridines: chemistry
000022269 650_2 $$2MeSH$$aRats
000022269 650_2 $$2MeSH$$aRats, Sprague-Dawley
000022269 650_2 $$2MeSH$$aReceptors, Metabotropic Glutamate: analysis
000022269 650_2 $$2MeSH$$aReproducibility of Results
000022269 650_7 $$00$$2NLM Chemicals$$a3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime
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000022269 7001_ $$0P:(DE-HGF)0$$aAliaga, A.$$b1
000022269 7001_ $$0P:(DE-Juel1)131672$$aBauer, A.$$b2$$uFZJ
000022269 7001_ $$0P:(DE-HGF)0$$aRosa-Neto, P.$$b3
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