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@ARTICLE{Elmenhorst:22269,
      author       = {Elmenhorst, D. and Aliaga, A. and Bauer, A. and Rosa-Neto,
                      P.},
      title        = {{T}est-{R}etest {S}tability of {C}erebral m{G}lu{R}5
                      {Q}uantification {U}sing [11{C}]{ABP}688 and {P}ositron
                      {E}mission {T}omography in {R}ats},
      journal      = {Synapse},
      volume       = {66},
      issn         = {0887-4476},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-22269},
      pages        = {552 - 560},
      year         = {2012},
      note         = {Contract grant sponsor: Heinrich Hertz Foundation of the
                      Ministry of Science and Technology; Contract grant sponsor:
                      North-Rhine Westfalia, Germany; Contract grant sponsor:
                      Alzheimer's Association new investigator award; Contract
                      grant number: NIRG-08-92090; Contract grant sponsor: Fonds
                      de la Recherche en Sante du Quebec (FRSQ); Contract grant
                      sponsor: Chercheur Burcier award (PRN); Contract grant
                      sponsor: Aisenstadt Foundation.},
      abstract     = {This study evaluates the reproducibility of the
                      quantification of metabotropic glutamate receptor type 5
                      (mGluR₅) densities in rats using the PET radiotracer
                      [¹¹C]ABP688 and pharmacokinetic models that are based on
                      an input function, which is derived from a reference tissue.
                      Seven rats underwent dynamic PET scans (60 min) after bolus
                      injection of [¹¹C]ABP688. Kinetic analyses included:
                      binding potential (BP(ND) ) determined by calculating (a)
                      the simplified reference tissue model (SRTM) and (b) its
                      two-steps simplified version (SRTM2); (c) multilinear
                      reference tissue model (MRTM) and (d) its 2-parameter
                      version (MRTM2); (e) noninvasive graphical analysis (NIGA).
                      Parametric images were generated representing BP(ND) by the
                      MRTM2 model. BP(ND) determinations were reproducible with
                      low to acceptable variability ranging from 5 to $10\%$ and
                      reproducibility scores (intraclass correlation coefficient)
                      between 0.51 and 0.88. The pharmacokinetic model that showed
                      lowest overall variability was the SRTM. In contrast, the
                      use of the NIGA was associated with significantly lower
                      reproducibility scores. Comparison of parametric images
                      revealed no significant bias between test and retest
                      measurements and is therefore suitable to compare groups at
                      voxel levels. In conclusion, our results suggest that
                      noninvasive quantification of [¹¹C]ABP688 imaging is
                      reproducible and reliable for PET studies of the cerebral
                      mGluR₅ in rats.},
      keywords     = {Algorithms / Animals / Brain: radionuclide imaging / Brain
                      Chemistry / Carbon Radioisotopes: chemistry / Image
                      Interpretation, Computer-Assisted / Kinetics / Male /
                      Oximes: analysis / Oximes: chemistry / Positron-Emission
                      Tomography: methods / Pyridines: analysis / Pyridines:
                      chemistry / Rats / Rats, Sprague-Dawley / Receptors,
                      Metabotropic Glutamate: analysis / Reproducibility of
                      Results /
                      3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime
                      (NLM Chemicals) / Carbon Radioisotopes (NLM Chemicals) /
                      Oximes (NLM Chemicals) / Pyridines (NLM Chemicals) /
                      Receptors, Metabotropic Glutamate (NLM Chemicals) /
                      metabotropic glutamate receptor 5 (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89574 - Theory, modelling and simulation (POF2-89574)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89574},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22290765},
      UT           = {WOS:000302293300009},
      doi          = {10.1002/syn.21542},
      url          = {https://juser.fz-juelich.de/record/22269},
}