Hauptseite > Publikationsdatenbank > Test-Retest Stability of Cerebral mGluR5 Quantification Using [11C]ABP688 and Positron Emission Tomography in Rats > print

001     22269
005     20210129210819.0
024 7 _ |2 pmid
|a pmid:22290765
024 7 _ |2 DOI
|a 10.1002/syn.21542
024 7 _ |2 WOS
|a WOS:000302293300009
024 7 _ |2 ISSN
|a 0887-4476
037 _ _ |a PreJuSER-22269
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-Juel1)131679
|a Elmenhorst, D.
|b 0
|u FZJ
245 _ _ |a Test-Retest Stability of Cerebral mGluR5 Quantification Using [11C]ABP688 and Positron Emission Tomography in Rats
260 _ _ |a New York, NY
|b Wiley-Liss
|c 2012
300 _ _ |a 552 - 560
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
|2 DRIVER
440 _ 0 |0 13481
|a Synapse
|v 66
|x 0887-4476
|y 6
500 _ _ |a Contract grant sponsor: Heinrich Hertz Foundation of the Ministry of Science and Technology; Contract grant sponsor: North-Rhine Westfalia, Germany; Contract grant sponsor: Alzheimer's Association new investigator award; Contract grant number: NIRG-08-92090; Contract grant sponsor: Fonds de la Recherche en Sante du Quebec (FRSQ); Contract grant sponsor: Chercheur Burcier award (PRN); Contract grant sponsor: Aisenstadt Foundation.
520 _ _ |a This study evaluates the reproducibility of the quantification of metabotropic glutamate receptor type 5 (mGluR₅) densities in rats using the PET radiotracer [¹¹C]ABP688 and pharmacokinetic models that are based on an input function, which is derived from a reference tissue. Seven rats underwent dynamic PET scans (60 min) after bolus injection of [¹¹C]ABP688. Kinetic analyses included: binding potential (BP(ND) ) determined by calculating (a) the simplified reference tissue model (SRTM) and (b) its two-steps simplified version (SRTM2); (c) multilinear reference tissue model (MRTM) and (d) its 2-parameter version (MRTM2); (e) noninvasive graphical analysis (NIGA). Parametric images were generated representing BP(ND) by the MRTM2 model. BP(ND) determinations were reproducible with low to acceptable variability ranging from 5 to 10% and reproducibility scores (intraclass correlation coefficient) between 0.51 and 0.88. The pharmacokinetic model that showed lowest overall variability was the SRTM. In contrast, the use of the NIGA was associated with significantly lower reproducibility scores. Comparison of parametric images revealed no significant bias between test and retest measurements and is therefore suitable to compare groups at voxel levels. In conclusion, our results suggest that noninvasive quantification of [¹¹C]ABP688 imaging is reproducible and reliable for PET studies of the cerebral mGluR₅ in rats.
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536 _ _ |0 G:(DE-HGF)POF2-89574
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Algorithms
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Brain: radionuclide imaging
650 _ 2 |2 MeSH
|a Brain Chemistry
650 _ 2 |2 MeSH
|a Carbon Radioisotopes: chemistry
650 _ 2 |2 MeSH
|a Image Interpretation, Computer-Assisted
650 _ 2 |2 MeSH
|a Kinetics
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Oximes: analysis
650 _ 2 |2 MeSH
|a Oximes: chemistry
650 _ 2 |2 MeSH
|a Positron-Emission Tomography: methods
650 _ 2 |2 MeSH
|a Pyridines: analysis
650 _ 2 |2 MeSH
|a Pyridines: chemistry
650 _ 2 |2 MeSH
|a Rats
650 _ 2 |2 MeSH
|a Rats, Sprague-Dawley
650 _ 2 |2 MeSH
|a Receptors, Metabotropic Glutamate: analysis
650 _ 2 |2 MeSH
|a Reproducibility of Results
650 _ 7 |0 0
|2 NLM Chemicals
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650 _ 7 |0 0
|2 NLM Chemicals
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650 _ 7 |0 0
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|a Oximes
650 _ 7 |0 0
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|a Pyridines
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Metabotropic Glutamate
650 _ 7 |0 0
|2 NLM Chemicals
|a metabotropic glutamate receptor 5
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a positron emission tomography
653 2 0 |2 Author
|a test-retest
653 2 0 |2 Author
|a kinetic modeling
653 2 0 |2 Author
|a [11C]ABP688
700 1 _ |0 P:(DE-HGF)0
|a Aliaga, A.
|b 1
700 1 _ |0 P:(DE-Juel1)131672
|a Bauer, A.
|b 2
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Rosa-Neto, P.
|b 3
773 _ _ |0 PERI:(DE-600)1474927-0
|a 10.1002/syn.21542
|g Vol. 66, p. 552 - 560
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|t Synapse
|v 66
|x 0887-4476
|y 2012
856 7 _ |u http://dx.doi.org/10.1002/syn.21542
909 C O |o oai:juser.fz-juelich.de:22269
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