000022450 001__ 22450
000022450 005__ 20231114132225.0
000022450 0247_ $$2pmid$$apmid:22727763
000022450 0247_ $$2DOI$$a10.1016/j.dcn.2012.05.001
000022450 0247_ $$2WOS$$aWOS:000315318000004
000022450 0247_ $$2altmetric$$aaltmetric:796733
000022450 0247_ $$2ISSN$$a1878-9307
000022450 037__ $$aPreJuSER-22450
000022450 041__ $$aeng
000022450 082__ $$a610
000022450 1001_ $$0P:(DE-Juel1)VDB67954$$aGilsbach, S.$$b0$$uFZJ
000022450 245__ $$aEffects of the DRD4 genotype on neural networks associated with executive functions in children and adolescents.
000022450 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2012
000022450 300__ $$a417 - 427
000022450 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000022450 3367_ $$2DataCite$$aOutput Types/Journal article
000022450 3367_ $$00$$2EndNote$$aJournal Article
000022450 3367_ $$2BibTeX$$aARTICLE
000022450 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000022450 3367_ $$2DRIVER$$aarticle
000022450 440_0 $$026363$$aDevelopmental Cognitive Neuroscience$$v2$$y4
000022450 500__ $$aRecord converted from VDB: 12.11.2012
000022450 520__ $$aGenetic variants within the dopamine D4 receptor gene (DRD4) are among the strongest and most consistently replicated molecular genetic findings in attentional functioning as well as attention deficit hyperactivity disorder (ADHD). Functionally, the 7-repeat allele of the DRD4-48 base pair repeat gene leads to a sub-sensitive postsynaptic D4 receptor, which is expressed at a particularly high density in the frontal lobes. We used fMRI to investigate the influence of the 7-repeat allele on BOLD (Blood Oxygen Level Dependency) responses in 26 healthy children and adolescents while they performed a combined stimulus-response Incompatibility Task (IC) and a Time Discrimination Task (TT). 7-repeat non-carriers exhibited increased neural activation of the left middle and inferior frontal gyrus (IFG) in the IC and greater cerebellar activation in the TT. Furthermore, the 7-repeat non-carriers exhibited a stronger coupling in haemodynamic responses between left IFG and the anterior cingulate cortex (ACC) during the IC and between cerebellar activation and brain regions that have high DRD4 density, including the IFG and the ACC during the TT. Our results indicate that the 7-repeat allele influences both regional brain activation patterns as well as connectivity patterns between neural networks of incompatibility and temporal processing.
000022450 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000022450 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000022450 588__ $$aDataset connected to Pubmed
000022450 7001_ $$0P:(DE-HGF)0$$aNeufang, S.$$b1
000022450 7001_ $$0P:(DE-HGF)0$$aScherag, S.$$b2
000022450 7001_ $$0P:(DE-HGF)0$$aVloet, T.D.$$b3
000022450 7001_ $$0P:(DE-Juel1)131720$$aFink, G.R.$$b4$$uFZJ
000022450 7001_ $$0P:(DE-HGF)0$$aHerpertz-Dahlmann, B.$$b5
000022450 7001_ $$0P:(DE-Juel1)VDB36136$$aKonrad, K.$$b6$$uFZJ
000022450 773__ $$0PERI:(DE-600)2572271-2$$a10.1016/j.dcn.2012.05.001$$gVol. 2, p. 417 - 427$$p417 - 427$$q2<417 - 427$$tDevelopmental Cognitive Neuroscience$$v2$$x1878-9293$$y2012
000022450 8567_ $$uhttp://dx.doi.org/10.1016/j.dcn.2012.05.001
000022450 909CO $$ooai:juser.fz-juelich.de:22450$$pVDB
000022450 915__ $$0StatID:(DE-HGF)0040$$2StatID$$aPeer Review unknown
000022450 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000022450 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000022450 9141_ $$y2012
000022450 9132_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000022450 9131_ $$0G:(DE-HGF)POF2-89571$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vConnectivity and Activity$$x1
000022450 9201_ $$0I:(DE-Juel1)INM-3-20090406$$gINM$$kINM-3$$lKognitive Neurowissenschaften$$x0
000022450 970__ $$aVDB:(DE-Juel1)139004
000022450 980__ $$aVDB
000022450 980__ $$aConvertedRecord
000022450 980__ $$ajournal
000022450 980__ $$aI:(DE-Juel1)INM-3-20090406
000022450 980__ $$aUNRESTRICTED