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@ARTICLE{Gilsbach:22450,
      author       = {Gilsbach, S. and Neufang, S. and Scherag, S. and Vloet,
                      T.D. and Fink, G.R. and Herpertz-Dahlmann, B. and Konrad,
                      K.},
      title        = {{E}ffects of the {DRD}4 genotype on neural networks
                      associated with executive functions in children and
                      adolescents.},
      journal      = {Developmental Cognitive Neuroscience},
      volume       = {2},
      issn         = {1878-9293},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-22450},
      pages        = {417 - 427},
      year         = {2012},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Genetic variants within the dopamine D4 receptor gene
                      (DRD4) are among the strongest and most consistently
                      replicated molecular genetic findings in attentional
                      functioning as well as attention deficit hyperactivity
                      disorder (ADHD). Functionally, the 7-repeat allele of the
                      DRD4-48 base pair repeat gene leads to a sub-sensitive
                      postsynaptic D4 receptor, which is expressed at a
                      particularly high density in the frontal lobes. We used fMRI
                      to investigate the influence of the 7-repeat allele on BOLD
                      (Blood Oxygen Level Dependency) responses in 26 healthy
                      children and adolescents while they performed a combined
                      stimulus-response Incompatibility Task (IC) and a Time
                      Discrimination Task (TT). 7-repeat non-carriers exhibited
                      increased neural activation of the left middle and inferior
                      frontal gyrus (IFG) in the IC and greater cerebellar
                      activation in the TT. Furthermore, the 7-repeat non-carriers
                      exhibited a stronger coupling in haemodynamic responses
                      between left IFG and the anterior cingulate cortex (ACC)
                      during the IC and between cerebellar activation and brain
                      regions that have high DRD4 density, including the IFG and
                      the ACC during the TT. Our results indicate that the
                      7-repeat allele influences both regional brain activation
                      patterns as well as connectivity patterns between neural
                      networks of incompatibility and temporal processing.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22727763},
      UT           = {WOS:000315318000004},
      doi          = {10.1016/j.dcn.2012.05.001},
      url          = {https://juser.fz-juelich.de/record/22450},
}