TY  - JOUR
AU  - Herz, D.M.
AU  - Christensen, M.S.
AU  - Reck, C.
AU  - Florin, E.
AU  - Barbe, M.T.
AU  - Stahlhut, C.
AU  - Pauls, K.A.
AU  - Tittgemeyer, M.
AU  - Siebner, H.R.
AU  - Timmermann, L.
TI  - Task-specific modulation of effective connectivity during two simple unimanual motor tasks: a 122-channel EEG study.
JO  - NeuroImage
VL  - 59
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - PreJuSER-22509
SP  - 3187 - 3193
PY  - 2012
N1  - This study was supported by funding of the German Research Foundation in the Clinical Research Group 219 LT. DMH was supported by the Koeln Fortune Program/Faculty of Medicine, University of Cologne and a grant from the Danish Medical Research Council (grant-nr. FSS 09-072163). HRS was supported by a Grant of Excellence "ContAct" from Lundbeckfonden (R59 A5399).
AB  - Neural oscillations are thought to underlie coupling of spatially remote neurons and gating of information within the human sensorimotor system. Here we tested the hypothesis that different unimanual motor tasks are specifically associated with distinct patterns of oscillatory coupling in human sensorimotor cortical areas. In 13 healthy, right-handed subjects, we recorded task-induced neural activity with 122-channel electroencephalography (EEG) while subjects performed fast self-paced extension-flexion movements with the right index finger and an isometric contraction of the right forearm. Task-related modulations of inter-regional coupling within a core motor network comprising the left primary motor cortex (M1), lateral premotor cortex (lPM) and supplementary motor area (SMA) were then modeled using dynamic causal modeling (DCM). A network model postulating coupling both within and across frequencies best captured observed spectral responses according to Bayesian model selection. DCM revealed dominant coupling within the β-band (13-30 Hz) between M1 and SMA during isometric contraction of the forearm, whereas fast repetitive finger movements were characterized by strong coupling within the γ-band (31-48 Hz) and between the θ- (4-7 Hz) and the γ-band. This coupling pattern was mainly expressed in connections from lPM to SMA and from lPM to M1. We infer that human manual motor control involves task-specific modulation of inter-regional oscillatory coupling both within and across distinct frequency bands. The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks.
KW  - Adolescent
KW  - Adult
KW  - Electroencephalography: methods
KW  - Female
KW  - Fingers: physiology
KW  - Humans
KW  - Isometric Contraction
KW  - Male
KW  - Motor Cortex: physiology
KW  - Nervous System Physiological Processes
KW  - Task Performance and Analysis
KW  - Young Adult
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22146753
UR  - <Go to ISI:>//WOS:000301090100014
DO  - DOI:10.1016/j.neuroimage.2011.11.042
UR  - https://juser.fz-juelich.de/record/22509
ER  -