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@ARTICLE{McWhirter:22537,
      author       = {McWhirter, J.L. and Noguchi, H. and Gompper, G.},
      title        = {{O}rdering and arrangement of deformed red blood cells in
                      flow through microcapillaries},
      journal      = {New journal of physics},
      volume       = {14},
      issn         = {1367-2630},
      address      = {[Bad Honnef]},
      publisher    = {Dt. Physikalische Ges.},
      reportid     = {PreJuSER-22537},
      pages        = {085026},
      year         = {2012},
      note         = {We thank I O Gotze, T Auth and M Peltomaki for helpful
                      discussions. Support of this work by the DFG through the
                      priority program 'Nano- and Microfluidics' is gratefully
                      acknowledged.},
      abstract     = {The shapes and alignment of elastic vesicles similar to red
                      blood cells (RBCs) in cylindrical capillary flow are
                      investigated by mesoscopic hydrodynamic simulations. We
                      study the collective flow behavior of many RBCs, where the
                      capillary diameter is comparable to the diameter of the
                      RBCs. Two essential control parameters are the RBC volume
                      fraction (the tube hematocrit, H-T), and the suspension flow
                      velocity. Depending on H-T, flow velocity and capillary
                      radius, the RBC suspension exhibits a disordered phase and
                      two distinct ordered phases, consisting of a single file of
                      parachute-shaped cells and a zigzag arrangement of
                      slipper-shaped cells, respectively. We argue that thermal
                      fluctuations, included in the simulation method, coupled to
                      hydrodynamic flows are important contributors to the RBC
                      morphology. We examine the changes to the phase structures
                      when the capillary diameter and the material properties
                      (bending rigidity kappa and stretching modulus mu) of the
                      model RBCs are varied, constructing phase diagrams for each
                      case. We focus on capillary diameters, which range from
                      about 1.0 to about 1.4 times the RBC long diameter. For the
                      smallest capillary diameter, the single-file arrangement
                      dominates; for the largest diameter, the ordered zigzag
                      arrangement begins to loose its stability and alternates
                      with an asymmetric structure with two lanes of differently
                      oriented cells. In simulations with long capillaries, the
                      coexistence of different phases can be observed.},
      keywords     = {J (WoSType)},
      cin          = {IAS-2 / ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      shelfmark    = {Physics, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000308362800001},
      doi          = {10.1088/1367-2630/14/8/085026},
      url          = {https://juser.fz-juelich.de/record/22537},
}