000022578 001__ 22578
000022578 005__ 20240619092039.0
000022578 0247_ $$2pmid$$apmid:22853639
000022578 0247_ $$2DOI$$a10.1021/ja303894g
000022578 0247_ $$2WOS$$aWOS:000307487200007
000022578 0247_ $$2MLZ$$adoi:10.1021/ja303894g
000022578 0247_ $$2altmetric$$aaltmetric:880097
000022578 037__ $$aPreJuSER-22578
000022578 041__ $$aeng
000022578 082__ $$a540
000022578 084__ $$2WoS$$aChemistry, Multidisciplinary
000022578 1001_ $$0P:(DE-HGF)0$$aGallat, F.-X.$$b0
000022578 245__ $$aA Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity
000022578 260__ $$aWashington, DC$$bAmerican Chemical Society$$c2012
000022578 300__ $$a13168
000022578 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000022578 3367_ $$2DataCite$$aOutput Types/Journal article
000022578 3367_ $$00$$2EndNote$$aJournal Article
000022578 3367_ $$2BibTeX$$aARTICLE
000022578 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000022578 3367_ $$2DRIVER$$aarticle
000022578 440_0 $$025743$$aJournal of the American Chemical Society$$v134$$y32
000022578 500__ $$aThe authors thank the ILL, the FRMII, and the Diamond Light Source for beamtime. We thank Bernhard Frick for his continuous support related to IN16 experiments and Douglas Tobias for critical reading of an early version of the manuscript. Financial support by the CEA, the CNRS, and the UJF is acknowledged, as well as a grant from the Agence Nationale de la Recherche (ANR-11-BSV5-027) to M.W. and an ILL PhD fellowship to F.-X.G. This work has benefited from the activities of the DLAB consortium funded by the EU (HPRI-2001-50065 and RII3-CT-2003-505925) and from UK EPSRC-funded activity within the ILL-EMBL Deuteration Laboratory (GR/R99393/01 and EP/C015452/1). The study has been supported by the European Commission under the 7th Framework Programme through the "Research Infrastructures" action of the "Capacities" Programme (CP-CSA_INFRA-2008-1.1.1 No. 226507-NMI3) and ERC Advanced Grant scheme (S.M.). We thank the EPSRC (Cross-disciplinary Interfaces Program) for support for AWP. C.J.J. was supported by a Marie Curie International Incoming Fellowship.
000022578 520__ $$aThe observation of biological activity in solvent-free protein-polymer surfactant hybrids challenges the view of aqueous and nonaqueous solvents being unique promoters of protein dynamics linked to function. Here, we combine elastic incoherent neutron scattering and specific deuterium labeling to separately study protein and polymer motions in solvent-free hybrids. Myoglobin motions within the hybrid are found to closely resemble those of a hydrated protein, and motions of the polymer surfactant coating are similar to those of the hydration water, leading to the conclusion that the polymer surfactant coating plasticizes protein structures in a way similar to hydration water.
000022578 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (FUEK505)$$cFUEK505$$x0
000022578 536__ $$0G:(DE-HGF)POF2-544$$a544 - In-house Research with PNI (POF2-544)$$cPOF2-544$$fPOF II$$x1
000022578 536__ $$0G:(EU-Grant)226507$$aNMI3 - Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy (226507)$$c226507$$fFP7-INFRASTRUCTURES-2008-1$$x2
000022578 588__ $$aDataset connected to Web of Science, Pubmed
000022578 650_7 $$2WoSType$$aJ
000022578 65027 $$0V:(DE-MLZ)SciArea-210$$2V:(DE-HGF)$$aSoft Condensed Matter$$x0
000022578 65017 $$0V:(DE-MLZ)GC-130-2016$$2V:(DE-HGF)$$aHealth and Life$$x1
000022578 65017 $$0V:(DE-MLZ)GC-130-1$$2V:(DE-HGF)$$aHealth and Life$$x0
000022578 693__ $$0EXP:(DE-MLZ)SPHERES-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)SPHERES-20140101$$6EXP:(DE-MLZ)NL6S-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz$$eSPHERES: Backscattering spectrometer$$fNL6S$$x0
000022578 7001_ $$0P:(DE-HGF)0$$aBrogan, A.P.S.$$b1
000022578 7001_ $$0P:(DE-HGF)0$$aFichou, Y.$$b2
000022578 7001_ $$0P:(DE-HGF)0$$aMcGrath, N.$$b3
000022578 7001_ $$0P:(DE-HGF)0$$aMoulin, M.$$b4
000022578 7001_ $$0P:(DE-HGF)0$$aHärtlein, M.$$b5
000022578 7001_ $$0P:(DE-HGF)0$$aCombet, J.$$b6
000022578 7001_ $$0P:(DE-Juel1)131044$$aWuttke, J.$$b7$$uFZJ
000022578 7001_ $$0P:(DE-HGF)0$$aMann, S.$$b8
000022578 7001_ $$0P:(DE-HGF)0$$aZaccai, G.$$b9
000022578 7001_ $$0P:(DE-HGF)0$$aJackson, C.J.$$b10
000022578 7001_ $$0P:(DE-HGF)0$$aPerriman, A.W.$$b11
000022578 7001_ $$0P:(DE-HGF)0$$aWeik, M.$$b12
000022578 773__ $$0PERI:(DE-600)1472210-0$$a10.1021/ja303894g$$gVol. 134, p. 13168$$p13168$$q134<13168$$tJournal of the American Chemical Society$$v134$$x0002-7863$$y2012
000022578 8567_ $$uhttp://dx.doi.org/10.1021/ja303894g
000022578 909CO $$ooai:juser.fz-juelich.de:22578$$pec_fundedresources$$pVDB$$pVDB:MLZ$$popenaire
000022578 915__ $$0StatID:(DE-HGF)0010$$2StatID$$aJCR/ISI refereed
000022578 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000022578 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000022578 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000022578 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000022578 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000022578 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000022578 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000022578 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000022578 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000022578 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000022578 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000022578 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000022578 9141_ $$y2012
000022578 9132_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000022578 9132_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$aDE-HGF$$bForschungsbereich Materie$$lIn-house research on the structure, dynamics and function of matter$$vNeutrons for Research on Condensed Matter$$x1
000022578 9131_ $$0G:(DE-HGF)POF2-544$$1G:(DE-HGF)POF2-540$$2G:(DE-HGF)POF2-500$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bStruktur der Materie$$lForschung mit Photonen, Neutronen, Ionen$$vIn-house Research with PNI$$x0
000022578 9201_ $$0I:(DE-Juel1)ICS-1-20110106$$gICS$$kICS-1$$lNeutronenstreuung$$x0
000022578 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II$$lJCNS-FRM-II$$x1
000022578 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$gJCNS$$kJCNS-1$$lNeutronenstreuung$$x2
000022578 970__ $$aVDB:(DE-Juel1)139241
000022578 980__ $$aVDB
000022578 980__ $$aConvertedRecord
000022578 980__ $$ajournal
000022578 980__ $$aI:(DE-Juel1)ICS-1-20110106
000022578 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000022578 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000022578 980__ $$aUNRESTRICTED
000022578 981__ $$aI:(DE-Juel1)IBI-8-20200312
000022578 981__ $$aI:(DE-Juel1)JCNS-1-20110106
000022578 981__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218