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@ARTICLE{Gallat:22578,
      author       = {Gallat, F.-X. and Brogan, A.P.S. and Fichou, Y. and
                      McGrath, N. and Moulin, M. and Härtlein, M. and Combet, J.
                      and Wuttke, J. and Mann, S. and Zaccai, G. and Jackson, C.J.
                      and Perriman, A.W. and Weik, M.},
      title        = {{A} {P}olymer {S}urfactant {C}orona {D}ynamically
                      {R}eplaces {W}ater in {S}olvent-{F}ree {P}rotein {L}iquids
                      and {E}nsures {M}acromolecular {F}lexibility and {A}ctivity},
      journal      = {Journal of the American Chemical Society},
      volume       = {134},
      issn         = {0002-7863},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-22578},
      pages        = {13168},
      year         = {2012},
      note         = {The authors thank the ILL, the FRMII, and the Diamond Light
                      Source for beamtime. We thank Bernhard Frick for his
                      continuous support related to IN16 experiments and Douglas
                      Tobias for critical reading of an early version of the
                      manuscript. Financial support by the CEA, the CNRS, and the
                      UJF is acknowledged, as well as a grant from the Agence
                      Nationale de la Recherche (ANR-11-BSV5-027) to M.W. and an
                      ILL PhD fellowship to F.-X.G. This work has benefited from
                      the activities of the DLAB consortium funded by the EU
                      (HPRI-2001-50065 and RII3-CT-2003-505925) and from UK
                      EPSRC-funded activity within the ILL-EMBL Deuteration
                      Laboratory (GR/R99393/01 and EP/C015452/1). The study has
                      been supported by the European Commission under the 7th
                      Framework Programme through the "Research Infrastructures"
                      action of the "Capacities" Programme
                      $(CP-CSA_INFRA-2008-1.1.1$ No. 226507-NMI3) and ERC Advanced
                      Grant scheme (S.M.). We thank the EPSRC (Cross-disciplinary
                      Interfaces Program) for support for AWP. C.J.J. was
                      supported by a Marie Curie International Incoming
                      Fellowship.},
      abstract     = {The observation of biological activity in solvent-free
                      protein-polymer surfactant hybrids challenges the view of
                      aqueous and nonaqueous solvents being unique promoters of
                      protein dynamics linked to function. Here, we combine
                      elastic incoherent neutron scattering and specific deuterium
                      labeling to separately study protein and polymer motions in
                      solvent-free hybrids. Myoglobin motions within the hybrid
                      are found to closely resemble those of a hydrated protein,
                      and motions of the polymer surfactant coating are similar to
                      those of the hydration water, leading to the conclusion that
                      the polymer surfactant coating plasticizes protein
                      structures in a way similar to hydration water.},
      keywords     = {J (WoSType)},
      cin          = {ICS-1 / JCNS (München) ; Jülich Centre for Neutron
                      Science JCNS (München) ; JCNS-FRM-II / JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-1-20110106 /
                      I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung (FUEK505) / 544 - In-house Research
                      with PNI (POF2-544) / NMI3 - Integrated Infrastructure
                      Initiative for Neutron Scattering and Muon Spectroscopy
                      (226507)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-HGF)POF2-544 /
                      G:(EU-Grant)226507},
      experiment   = {EXP:(DE-MLZ)SPHERES-20140101},
      shelfmark    = {Chemistry, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22853639},
      UT           = {WOS:000307487200007},
      doi          = {10.1021/ja303894g},
      url          = {https://juser.fz-juelich.de/record/22578},
}