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000022758 084__ $$2WoS$$aBiochemical Research Methods
000022758 084__ $$2WoS$$aMathematical & Computational Biology
000022758 1001_ $$0P:(DE-HGF)0$$aGonzales, O.J.A.$$b0
000022758 245__ $$aExternal Drive to Inhibitory Cells Induces Alternating Episodes of High- and Low-Amplitude Oscillations
000022758 260__ $$aSan Francisco, Calif.$$bPublic Library of Science$$c2012
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000022758 500__ $$aOJAG was supported by a grant from the EC Marie Curie Research and Training Network (RTN), NEURoVERS-it 019247. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
000022758 520__ $$aElectrical oscillations in neuronal network activity are ubiquitous in the brain and have been associated with cognition and behavior. Intriguingly, the amplitude of ongoing oscillations, such as measured in EEG recordings, fluctuates irregularly, with episodes of high amplitude alternating with episodes of low amplitude. Despite the widespread occurrence of amplitude fluctuations in many frequency bands and brain regions, the mechanisms by which they are generated are poorly understood. Here, we show that irregular transitions between sub-second episodes of high- and low-amplitude oscillations in the alpha/beta frequency band occur in a generic neuronal network model consisting of interconnected inhibitory and excitatory cells that are externally driven by sustained cholinergic input and trains of action potentials that activate excitatory synapses. In the model, we identify the action potential drive onto inhibitory cells, which represents input from other brain areas and is shown to desynchronize network activity, to be crucial for the emergence of amplitude fluctuations. We show that the duration distributions of high-amplitude episodes in the model match those observed in rat prefrontal cortex for oscillations induced by the cholinergic agonist carbachol. Furthermore, the mean duration of high-amplitude episodes varies in a bell-shaped manner with carbachol concentration, just as in mouse hippocampus. Our results suggest that amplitude fluctuations are a general property of oscillatory neuronal networks that can arise through background input from areas external to the network.
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000022758 7001_ $$0P:(DE-Juel1)VDB93155$$avan Aerde, K.I.$$b1$$uFZJ
000022758 7001_ $$0P:(DE-HGF)0$$avan Elburg, R.A.J.$$b2
000022758 7001_ $$0P:(DE-HGF)0$$aPoil, S.S.$$b3
000022758 7001_ $$0P:(DE-HGF)0$$aMansvelder, H.D.$$b4
000022758 7001_ $$0P:(DE-HGF)0$$aLinkenkaer-Hansen, K.$$b5
000022758 7001_ $$0P:(DE-HGF)0$$avan Pelt, J.$$b6
000022758 7001_ $$0P:(DE-HGF)0$$avan Ooyen, A.$$b7
000022758 773__ $$0PERI:(DE-600)2193340-6$$a10.1371/journal.pcbi.1002666$$gVol. 8, p. e1002666$$pe1002666$$q8<e1002666$$tPLoS Computational Biology$$v8$$x1553-7358$$y2012
000022758 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431298
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