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@ARTICLE{Gonzales:22758,
      author       = {Gonzales, O.J.A. and van Aerde, K.I. and van Elburg, R.A.J.
                      and Poil, S.S. and Mansvelder, H.D. and Linkenkaer-Hansen,
                      K. and van Pelt, J. and van Ooyen, A.},
      title        = {{E}xternal {D}rive to {I}nhibitory {C}ells {I}nduces
                      {A}lternating {E}pisodes of {H}igh- and {L}ow-{A}mplitude
                      {O}scillations},
      journal      = {PLoS Computational Biology},
      volume       = {8},
      issn         = {1553-7358},
      address      = {San Francisco, Calif.},
      publisher    = {Public Library of Science},
      reportid     = {PreJuSER-22758},
      pages        = {e1002666},
      year         = {2012},
      note         = {OJAG was supported by a grant from the EC Marie Curie
                      Research and Training Network (RTN), NEURoVERS-it 019247.
                      The funders had no role in study design, data collection and
                      analysis, decision to publish, or preparation of the
                      manuscript.},
      abstract     = {Electrical oscillations in neuronal network activity are
                      ubiquitous in the brain and have been associated with
                      cognition and behavior. Intriguingly, the amplitude of
                      ongoing oscillations, such as measured in EEG recordings,
                      fluctuates irregularly, with episodes of high amplitude
                      alternating with episodes of low amplitude. Despite the
                      widespread occurrence of amplitude fluctuations in many
                      frequency bands and brain regions, the mechanisms by which
                      they are generated are poorly understood. Here, we show that
                      irregular transitions between sub-second episodes of high-
                      and low-amplitude oscillations in the alpha/beta frequency
                      band occur in a generic neuronal network model consisting of
                      interconnected inhibitory and excitatory cells that are
                      externally driven by sustained cholinergic input and trains
                      of action potentials that activate excitatory synapses. In
                      the model, we identify the action potential drive onto
                      inhibitory cells, which represents input from other brain
                      areas and is shown to desynchronize network activity, to be
                      crucial for the emergence of amplitude fluctuations. We show
                      that the duration distributions of high-amplitude episodes
                      in the model match those observed in rat prefrontal cortex
                      for oscillations induced by the cholinergic agonist
                      carbachol. Furthermore, the mean duration of high-amplitude
                      episodes varies in a bell-shaped manner with carbachol
                      concentration, just as in mouse hippocampus. Our results
                      suggest that amplitude fluctuations are a general property
                      of oscillatory neuronal networks that can arise through
                      background input from areas external to the network.},
      keywords     = {J (WoSType)},
      cin          = {INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Biochemical Research Methods / Mathematical $\&$
                      Computational Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22956901},
      pmc          = {pmc:PMC3431298},
      UT           = {WOS:000308553500044},
      doi          = {10.1371/journal.pcbi.1002666},
      url          = {https://juser.fz-juelich.de/record/22758},
}