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@ARTICLE{Mainz:22778,
      author       = {Mainz, V. and Schulte-Rüther, M. and Fink, G.R. and
                      Herpertz-Dahlmann, B. and Konrad, K.},
      title        = {{S}tructural brain abnormalities in adolescent anorexia
                      nervosa before and after weight recovery and associated
                      hormonal changes},
      journal      = {Psychosomatic medicine},
      volume       = {74},
      issn         = {0033-3174},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {PreJuSER-22778},
      pages        = {574 - 582},
      year         = {2012},
      note         = {This study was supported by a grant of the German Ministry
                      for Education and Research (01GV0602) to Drs.
                      Herpertz-Dahlmann and Konrad.},
      abstract     = {The neurobiological mechanisms of structural brain
                      abnormalities in patients with anorexia nervosa (AN) remain
                      poorly understood. In particular, little is known about the
                      changes in and the recovery of gray matter (GM) volumes
                      after weight gain and the relation to hormonal normalization
                      in adolescent patients with AN.Nineteen female patients aged
                      12 to 17 years were assessed using magnetic resonance
                      imaging at the time of admission to the hospital (T1) and
                      after weight recovery (T2). Patients were compared with
                      typically developing girls matched for age and intelligence
                      quotient. Structural brain images were analyzed using a
                      voxel-based morphometric approach. Circulating levels of
                      cortisol and gonadotropins were assessed in blood
                      samples.Compared with controls, patients with AN showed
                      reduced GM in several brain regions along the cortical
                      midline, reaching from the occipital cortex to the medial
                      frontal areas. These GM reductions were mostly reversible at
                      T1. Patients showed a GM increase from T1 to T2 along the
                      cortical midline and in the occipital, temporal, parietal,
                      and frontal lobes. GM increases at T2 correlated inversely
                      with cortisol levels at T1 and positively with weight gain
                      at T2. The strongest associations between regional GM
                      increase and weight gain were found in the cerebellum. In
                      addition, increases in GM volumes at T2 in the thalamus,
                      hippocampus, and amygdala were associated with increases in
                      follicle-stimulating hormone.Our data suggest that brain
                      alterations in adolescents with acute AN are mostly
                      reversible at T1 and that GM recovery in specific brain
                      regions is associated with weight and hormonal
                      normalization.},
      keywords     = {J (WoSType)},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Psychiatry / Psychology / Psychology, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22511729},
      UT           = {WOS:000306531700003},
      doi          = {10.1097/PSY.0b013e31824ef10e},
      url          = {https://juser.fz-juelich.de/record/22778},
}